Relationship of 2D Affinity to T Cell Functional Outcomes
Abstract
:1. Introduction
2. The Affinity Measurements of TCR
2.1. 3D Methods of Measuring Affinity
2.2. 2D Methods of Measuring Affinity
3. Are Lower Affinity T Cells Real?
3.1. Low Sensitivity Techniques
3.2. Specificity with High Sensitivity by 2D-Micropipette
4. Expansion and Frequency of Low Affinity CD4+ T Cells
5. The Affinity of TCR for pMHC Modulates TCR-Derived Signals
6. Factors Influencing Expansion of Lower Affinity T Cells in Addition to 2D Affinity of the TCR for pMHC
6.1. Differential Signaling from Co-Receptors
6.2. Bond Lifetime under Force: A Key Predictor of T Cell Function
7. Affinity Profile and CD4+ T Cell Effector Phenotypes
7.1. T Effector Cells (Teff)
7.2. T Follicular Helper Cells (Tfh)
7.3. Tregs
7.4. Memory T Cells
8. High and Low Affinity CD8+ T Cells
8.1. Effector CD8+ T Cells
8.2. Memory CD8+ T Cells
9. Conclusions
Funding
Conflicts of Interest
References
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Kolawole, E.M.; Lamb, T.J.; Evavold, B.D. Relationship of 2D Affinity to T Cell Functional Outcomes. Int. J. Mol. Sci. 2020, 21, 7969. https://doi.org/10.3390/ijms21217969
Kolawole EM, Lamb TJ, Evavold BD. Relationship of 2D Affinity to T Cell Functional Outcomes. International Journal of Molecular Sciences. 2020; 21(21):7969. https://doi.org/10.3390/ijms21217969
Chicago/Turabian StyleKolawole, Elizabeth M., Tracey J. Lamb, and Brian D. Evavold. 2020. "Relationship of 2D Affinity to T Cell Functional Outcomes" International Journal of Molecular Sciences 21, no. 21: 7969. https://doi.org/10.3390/ijms21217969