Emerging Links between Control of Mitochondrial Protein ATAD3A and Cancer
Abstract
:1. Introduction
2. The Essential Role of ATAD3A in Mitochondria
2.1. The Molecular Structure of ATAD3A in Mitochondria
2.2. Functions of ATAD3A in Mitochondria Homeostasis
2.3. The Role of ATAD3A in Mitochondrial Metabolism and Respiration
3. ATAD3A in Cancer
3.1. Elevated ATAD3A Expression in Cancers
3.2. ATAD3A Promotes Tumor Growth
3.3. ATAD3A Facilitates Cancer Metastasis
4. ATAD3A in Other Diseases
5. ATAD3A and Treatment Responses
5.1. ATAD3A Is Engaged in Chemo-Resistance
5.2. ATAD3A Is Engaged in Radio-Resistance
6. Anti-Cancer Targeting of ATAD3A and Family Members
6.1. ATAD3A as a Potential Novel Target for Cancer Therapy
6.2. ATAD3 Family Members and Potential Synergistic Anti-Cancer Targeting
7. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
ATAD3A | ATPase family AAA domain-containing protein 3A |
a.a. | amino acids |
DRP1 | dynamin-related protein 1 |
dATAD3A | drosophila ATAD3A |
ER | endoplasmic reticulum |
HNSCC | head and neck squamous carcinoma |
FAT1 | Fat 1 protein |
HDR | homology-directed repair |
IM | inner membrane |
LADC | lung adenocarcinoma |
mtDNA | mitochondrial DNA |
SHRs | steroid hormone receptors |
siRNA | small interfering RNA |
OM | outer membrane |
TAP-MS | tandem affinity purification and mass spectrometry |
TM | transmembrane |
TOR | target of rapamycin |
UCC | urothelial carcinoma |
VDAC | voltage-dependent anion channel |
WA | Walker A |
WASF3 | Wiskott–Aldridge syndrome family protein 3 |
WB | Walker B |
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Lang, L.; Loveless, R.; Teng, Y. Emerging Links between Control of Mitochondrial Protein ATAD3A and Cancer. Int. J. Mol. Sci. 2020, 21, 7917. https://doi.org/10.3390/ijms21217917
Lang L, Loveless R, Teng Y. Emerging Links between Control of Mitochondrial Protein ATAD3A and Cancer. International Journal of Molecular Sciences. 2020; 21(21):7917. https://doi.org/10.3390/ijms21217917
Chicago/Turabian StyleLang, Liwei, Reid Loveless, and Yong Teng. 2020. "Emerging Links between Control of Mitochondrial Protein ATAD3A and Cancer" International Journal of Molecular Sciences 21, no. 21: 7917. https://doi.org/10.3390/ijms21217917