Perspective: Quality Versus Quantity; Is It Important to Assess the Role of Enhancers in Complex Disease from an In Vivo Perspective?
Abstract
:1. Introduction
What Is the Regulatory Genome?
2. Identifying Enhancer Sequences; Lessons from Developmental Biology
3. Chromatin Markers
4. An Evolutionary Perspective
5. Conserved Enhancers in Adult Brain Activity
6. Gene Regulation and Pharmacogenomics?
7. Enhancers as Future Personalised Drug Targets?
8. Nature Versus Nurture: Epigenetics and the Functional Non-Coding Genome
9. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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McEwan, A.R.; MacKenzie, A. Perspective: Quality Versus Quantity; Is It Important to Assess the Role of Enhancers in Complex Disease from an In Vivo Perspective? Int. J. Mol. Sci. 2020, 21, 7856. https://doi.org/10.3390/ijms21217856
McEwan AR, MacKenzie A. Perspective: Quality Versus Quantity; Is It Important to Assess the Role of Enhancers in Complex Disease from an In Vivo Perspective? International Journal of Molecular Sciences. 2020; 21(21):7856. https://doi.org/10.3390/ijms21217856
Chicago/Turabian StyleMcEwan, Andrew R., and Alasdair MacKenzie. 2020. "Perspective: Quality Versus Quantity; Is It Important to Assess the Role of Enhancers in Complex Disease from an In Vivo Perspective?" International Journal of Molecular Sciences 21, no. 21: 7856. https://doi.org/10.3390/ijms21217856