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The Physiological and Pathological Roles of Mitochondrial Calcium Uptake in Heart

by Lo Lai and Hongyu Qiu *
Center for Molecular and Translational Medicine, Institute of Biomedical Science, Georgia State University, 100 Piedmont Ave, PSC 588, Atlanta, GA 30303, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(20), 7689; https://doi.org/10.3390/ijms21207689
Received: 14 September 2020 / Revised: 12 October 2020 / Accepted: 16 October 2020 / Published: 17 October 2020
(This article belongs to the Special Issue Mitochondrial Calcium Signaling)
Calcium ion (Ca2+) plays a critical role in the cardiac mitochondria function. Ca2+ entering the mitochondria is necessary for ATP production and the contractile activity of cardiomyocytes. However, excessive Ca2+ in the mitochondria results in mitochondrial dysfunction and cell death. Mitochondria maintain Ca2+ homeostasis in normal cardiomyocytes through a comprehensive regulatory mechanism by controlling the uptake and release of Ca2+ in response to the cellular demand. Understanding the mechanism of modulating mitochondrial Ca2+ homeostasis in the cardiomyocyte could bring new insights into the pathogenesis of cardiac disease and help developing the strategy to prevent the heart from damage at an early stage. In this review, we summarized the latest findings in the studies on the cardiac mitochondrial Ca2+ homeostasis, focusing on the regulation of mitochondrial calcium uptake, which acts as a double-edged sword in the cardiac function. Specifically, we discussed the dual roles of mitochondrial Ca2+ in mitochondrial activity and the impact on cardiac function, the molecular basis and regulatory mechanisms, and the potential future research interest. View Full-Text
Keywords: mitochondria; Ca2+ uptake; cardiac function; heart failure; valosin-containing protein mitochondria; Ca2+ uptake; cardiac function; heart failure; valosin-containing protein
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MDPI and ACS Style

Lai, L.; Qiu, H. The Physiological and Pathological Roles of Mitochondrial Calcium Uptake in Heart. Int. J. Mol. Sci. 2020, 21, 7689.

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