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Open AccessReview

Synthetic Biology on Acetogenic Bacteria for Highly Efficient Conversion of C1 Gases to Biochemicals

1
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea
2
KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea
3
BBSRC/EPSRC Synthetic Biology Research Centre (SBRC), School of Life Sciences, University Park, The University of Nottingham, Nottingham NG7 2RD, UK
4
Université de Toulouse, INSA, UPS, INP, LISBP, 31400 Toulouse, France
5
Institut National de la Recherche Agronomique (INRA), UMR 792, 31077 Toulouse, France
6
Centre National de la Recherche Scientifique (CNRS), UMR 5504, 31400 Toulouse, France
7
Innovative Biomaterials Center, Daejeon 34141, Korea
8
Intelligent Synthetic Biology Center, Daejeon 34141, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(20), 7639; https://doi.org/10.3390/ijms21207639
Received: 25 September 2020 / Revised: 13 October 2020 / Accepted: 13 October 2020 / Published: 15 October 2020
(This article belongs to the Special Issue Microbial Systems and Synthetic Biology)
Synthesis gas, which is mainly produced from fossil fuels or biomass gasification, consists of C1 gases such as carbon monoxide, carbon dioxide, and methane as well as hydrogen. Acetogenic bacteria (acetogens) have emerged as an alternative solution to recycle C1 gases by converting them into value-added biochemicals using the Wood-Ljungdahl pathway. Despite the advantage of utilizing acetogens as biocatalysts, it is difficult to develop industrial-scale bioprocesses because of their slow growth rates and low productivities. To solve these problems, conventional approaches to metabolic engineering have been applied; however, there are several limitations owing to the lack of required genetic bioparts for regulating their metabolic pathways. Recently, synthetic biology based on genetic parts, modules, and circuit design has been actively exploited to overcome the limitations in acetogen engineering. This review covers synthetic biology applications to design and build industrial platform acetogens. View Full-Text
Keywords: acetogenic bacteria; C1 gas fixation; synthetic biology; CRISPR-Cas acetogenic bacteria; C1 gas fixation; synthetic biology; CRISPR-Cas
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MDPI and ACS Style

Jin, S.; Bae, J.; Song, Y.; Pearcy, N.; Shin, J.; Kang, S.; Minton, N.P.; Soucaille, P.; Cho, B.-K. Synthetic Biology on Acetogenic Bacteria for Highly Efficient Conversion of C1 Gases to Biochemicals. Int. J. Mol. Sci. 2020, 21, 7639.

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