Next Article in Journal
Cellular and Molecular Mechanisms of CD8+ T Cell Differentiation, Dysfunction and Exhaustion
Previous Article in Journal
Tissue-Specific Delivery of CRISPR Therapeutics: Strategies and Mechanisms of Non-Viral Vectors
Review

Microtubule Dysfunction: A Common Feature of Neurodegenerative Diseases

Unit of Neuromuscular and Neurodegenerative Disorders, Genetics and Rare Diseases Research Division, Bambino Gesù Children’s Hospital, IRCCS, 00146 Rome, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(19), 7354; https://doi.org/10.3390/ijms21197354
Received: 8 September 2020 / Revised: 24 September 2020 / Accepted: 1 October 2020 / Published: 5 October 2020
(This article belongs to the Section Molecular Neurobiology)
Neurons are particularly susceptible to microtubule (MT) defects and deregulation of the MT cytoskeleton is considered to be a common insult during the pathogenesis of neurodegenerative disorders. Evidence that dysfunctions in the MT system have a direct role in neurodegeneration comes from findings that several forms of neurodegenerative diseases are associated with changes in genes encoding tubulins, the structural units of MTs, MT-associated proteins (MAPs), or additional factors such as MT modifying enzymes which modulating tubulin post-translational modifications (PTMs) regulate MT functions and dynamics. Efforts to use MT-targeting therapeutic agents for the treatment of neurodegenerative diseases are underway. Many of these agents have provided several benefits when tested on both in vitro and in vivo neurodegenerative model systems. Currently, the most frequently addressed therapeutic interventions include drugs that modulate MT stability or that target tubulin PTMs, such as tubulin acetylation. The purpose of this review is to provide an update on the relevance of MT dysfunctions to the process of neurodegeneration and briefly discuss advances in the use of MT-targeting drugs for the treatment of neurodegenerative disorders. View Full-Text
Keywords: microtubules; neurodegeneration; microtubule dysfunctions; microtubule-targeting compounds microtubules; neurodegeneration; microtubule dysfunctions; microtubule-targeting compounds
Show Figures

Figure 1

MDPI and ACS Style

Sferra, A.; Nicita, F.; Bertini, E. Microtubule Dysfunction: A Common Feature of Neurodegenerative Diseases. Int. J. Mol. Sci. 2020, 21, 7354. https://doi.org/10.3390/ijms21197354

AMA Style

Sferra A, Nicita F, Bertini E. Microtubule Dysfunction: A Common Feature of Neurodegenerative Diseases. International Journal of Molecular Sciences. 2020; 21(19):7354. https://doi.org/10.3390/ijms21197354

Chicago/Turabian Style

Sferra, Antonella, Francesco Nicita, and Enrico Bertini. 2020. "Microtubule Dysfunction: A Common Feature of Neurodegenerative Diseases" International Journal of Molecular Sciences 21, no. 19: 7354. https://doi.org/10.3390/ijms21197354

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop