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The Emerging Role of the RNA-Binding Protein SFPQ in Neuronal Function and Neurodegeneration

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(19), 7151; https://doi.org/10.3390/ijms21197151
Received: 28 August 2020 / Revised: 24 September 2020 / Accepted: 25 September 2020 / Published: 28 September 2020
(This article belongs to the Special Issue RNA-Binding Proteins in Human Diseases—from Mechanisms to Therapies)
RNA-binding proteins (RBPs) are a class of proteins known for their diverse roles in RNA biogenesis, from regulating transcriptional processes in the nucleus to facilitating translation in the cytoplasm. With higher demand for RNA metabolism in the nervous system, RBP misregulation has been linked to a wide range of neurological and neurodegenerative diseases. One of the emerging RBPs implicated in neuronal function and neurodegeneration is splicing factor proline- and glutamine-rich (SFPQ). SFPQ is a ubiquitous and abundant RBP that plays multiple regulatory roles in the nucleus such as paraspeckle formation, DNA damage repair, and various transcriptional regulation processes. An increasing number of studies have demonstrated the nuclear and also cytoplasmic roles of SFPQ in neurons, particularly in post-transcriptional regulation and RNA granule formation. Not surprisingly, the misregulation of SFPQ has been linked to pathological features shown by other neurodegenerative disease-associated RBPs such as aberrant RNA splicing, cytoplasmic mislocalization, and aggregation. In this review, we discuss recent findings on the roles of SFPQ with a particular focus on those in neuronal development and homeostasis as well as its implications in neurodegenerative diseases. View Full-Text
Keywords: SFPQ; DBHS protein family; Drosophila behavior human splicing; RNA-binding protein; nuclear protein; neurodegenerative disease; cytoplasmic aggregation; stress granules SFPQ; DBHS protein family; Drosophila behavior human splicing; RNA-binding protein; nuclear protein; neurodegenerative disease; cytoplasmic aggregation; stress granules
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MDPI and ACS Style

Lim, Y.W.; James, D.; Huang, J.; Lee, M. The Emerging Role of the RNA-Binding Protein SFPQ in Neuronal Function and Neurodegeneration. Int. J. Mol. Sci. 2020, 21, 7151. https://doi.org/10.3390/ijms21197151

AMA Style

Lim YW, James D, Huang J, Lee M. The Emerging Role of the RNA-Binding Protein SFPQ in Neuronal Function and Neurodegeneration. International Journal of Molecular Sciences. 2020; 21(19):7151. https://doi.org/10.3390/ijms21197151

Chicago/Turabian Style

Lim, Yee W., Dylan James, Jie Huang, and Mihwa Lee. 2020. "The Emerging Role of the RNA-Binding Protein SFPQ in Neuronal Function and Neurodegeneration" International Journal of Molecular Sciences 21, no. 19: 7151. https://doi.org/10.3390/ijms21197151

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