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The Role of microRNAs in Epithelial Ovarian Cancer Metastasis

1
Department of Biology, York University, Toronto, ON M3J 1P3, Canada
2
Centre for Research in Biomolecular Interactions, York University, Toronto, ON M3J 1P3, Canada
*
Author to whom correspondence should be addressed.
Current Address: Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Int. J. Mol. Sci. 2020, 21(19), 7093; https://doi.org/10.3390/ijms21197093
Received: 10 September 2020 / Revised: 22 September 2020 / Accepted: 23 September 2020 / Published: 25 September 2020
(This article belongs to the Special Issue Molecular Mechanisms of Ovarian Cancer Development and Metastasis 2.0)
Epithelial ovarian cancer (EOC) is the deadliest gynecological cancer, and the major cause of death is mainly attributed to metastasis. MicroRNAs (miRNAs) are a group of small non-coding RNAs that exert important regulatory functions in many biological processes through their effects on regulating gene expression. In most cases, miRNAs interact with the 3′ UTRs of target mRNAs to induce their degradation and suppress their translation. Aberrant expression of miRNAs has been detected in EOC tumors and/or the biological fluids of EOC patients. Such dysregulation occurs as the result of alterations in DNA copy numbers, epigenetic regulation, and miRNA biogenesis. Many studies have demonstrated that miRNAs can promote or suppress events related to EOC metastasis, such as cell migration, invasion, epithelial-to-mesenchymal transition, and interaction with the tumor microenvironment. In this review, we provide a brief overview of miRNA biogenesis and highlight some key events and regulations related to EOC metastasis. We summarize current knowledge on how miRNAs are dysregulated, focusing on those that have been reported to regulate metastasis. Furthermore, we discuss the role of miRNAs in promoting and inhibiting EOC metastasis. Finally, we point out some limitations of current findings and suggest future research directions in the field. View Full-Text
Keywords: epithelial ovarian cancer; metastasis; microRNAs (miRNAs) epithelial ovarian cancer; metastasis; microRNAs (miRNAs)
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Nguyen, V.H.L.; Yue, C.; Du, K.Y.; Salem, M.; O'Brien, J.; Peng, C. The Role of microRNAs in Epithelial Ovarian Cancer Metastasis. Int. J. Mol. Sci. 2020, 21, 7093.

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