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Review

What Role Does COA6 Play in Cytochrome C Oxidase Biogenesis: A Metallochaperone or Thiol Oxidoreductase, or Both?

1
School of Chemistry and The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville 3010, Australia
2
Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton 3800, Australia
3
Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne 3086, Australia
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(19), 6983; https://doi.org/10.3390/ijms21196983
Received: 31 August 2020 / Revised: 21 September 2020 / Accepted: 21 September 2020 / Published: 23 September 2020
Complex IV (cytochrome c oxidase; COX) is the terminal complex of the mitochondrial electron transport chain. Copper is essential for COX assembly, activity, and stability, and is incorporated into the dinuclear CuA and mononuclear CuB sites. Multiple assembly factors play roles in the biogenesis of these sites within COX and the failure of this intricate process, such as through mutations to these factors, disrupts COX assembly and activity. Various studies over the last ten years have revealed that the assembly factor COA6, a small intermembrane space-located protein with a twin CX9C motif, plays a role in the biogenesis of the CuA site. However, how COA6 and its copper binding properties contribute to the assembly of this site has been a controversial area of research. In this review, we summarize our current understanding of the molecular mechanisms by which COA6 participates in COX biogenesis. View Full-Text
Keywords: mitochondria; cytochrome c oxidase; assembly factor; COA6; copper; structure mitochondria; cytochrome c oxidase; assembly factor; COA6; copper; structure
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MDPI and ACS Style

Maghool, S.; Ryan, M.T.; Maher, M.J. What Role Does COA6 Play in Cytochrome C Oxidase Biogenesis: A Metallochaperone or Thiol Oxidoreductase, or Both? Int. J. Mol. Sci. 2020, 21, 6983. https://doi.org/10.3390/ijms21196983

AMA Style

Maghool S, Ryan MT, Maher MJ. What Role Does COA6 Play in Cytochrome C Oxidase Biogenesis: A Metallochaperone or Thiol Oxidoreductase, or Both? International Journal of Molecular Sciences. 2020; 21(19):6983. https://doi.org/10.3390/ijms21196983

Chicago/Turabian Style

Maghool, Shadi, Michael T. Ryan, and Megan J. Maher 2020. "What Role Does COA6 Play in Cytochrome C Oxidase Biogenesis: A Metallochaperone or Thiol Oxidoreductase, or Both?" International Journal of Molecular Sciences 21, no. 19: 6983. https://doi.org/10.3390/ijms21196983

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