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Vitamin D and Cardiovascular Disease, with Emphasis on Hypertension, Atherosclerosis, and Heart Failure

Department. of Biomedical Sciences, University of Veterinary Medicine, 1210 Vienna, Austria
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Int. J. Mol. Sci. 2020, 21(18), 6483; https://doi.org/10.3390/ijms21186483
Received: 3 August 2020 / Revised: 24 August 2020 / Accepted: 31 August 2020 / Published: 4 September 2020
(This article belongs to the Special Issue Comorbidities in Chronic Diseases: Molecular Markers and Therapies)
Vitamin D deficiency is the most common nutritional deficiency, affecting almost one billion people worldwide. Vitamin D is mostly known for its role in intestinal calcium absorption and bone mineralization. However, the observation of seasonal changes in blood pressure and the subsequent identification of vitamin D receptor (VDR) and 1α-hydroxylase in cardiomyocytes, as well as endothelial and vascular smooth muscle cells, implicated a role of vitamin D in the cardiovascular system. Animal studies provided compelling evidence that vitamin D signaling is essential for cardiovascular integrity, especially for the regulation of vascular tone and as an antifibrotic and antihypertrophic signaling pathway in the heart. In addition, observational studies reported an association between vitamin D deficiency and risk of hypertension, atherosclerosis, and heart failure. However, recent clinical intervention studies failed to prove the causal relationship between vitamin D supplementation and beneficial effects on cardiovascular health. In this review, we aim to highlight our current understanding of the role of vitamin D in the cardiovascular system and to find potential explanations for the large discrepancies between the outcome of experimental studies and clinical intervention trials. View Full-Text
Keywords: vitamin D; cardiovascular disease; hypertension; atherosclerosis; endothelial dysfunction; heart failure vitamin D; cardiovascular disease; hypertension; atherosclerosis; endothelial dysfunction; heart failure
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MDPI and ACS Style

Latic, N.; Erben, R.G. Vitamin D and Cardiovascular Disease, with Emphasis on Hypertension, Atherosclerosis, and Heart Failure. Int. J. Mol. Sci. 2020, 21, 6483. https://doi.org/10.3390/ijms21186483

AMA Style

Latic N, Erben RG. Vitamin D and Cardiovascular Disease, with Emphasis on Hypertension, Atherosclerosis, and Heart Failure. International Journal of Molecular Sciences. 2020; 21(18):6483. https://doi.org/10.3390/ijms21186483

Chicago/Turabian Style

Latic, Nejla; Erben, Reinhold G. 2020. "Vitamin D and Cardiovascular Disease, with Emphasis on Hypertension, Atherosclerosis, and Heart Failure" Int. J. Mol. Sci. 21, no. 18: 6483. https://doi.org/10.3390/ijms21186483

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