Proteostasis and Proteotoxicity in the Network Medicine Era
Abstract
1. Introduction
2. The Proteostasis Network
2.1. Molecular Chaperones
2.2. Protein Degradation
3. The Failure of the PN in Neurodegeneration
4. Targeting the PN in Neurodegeneration: “Classical” Pharmacological Approaches
5. Novel Strategies to Ameliorate Proteinopathies: The “Network Medicine” Approach
5.1. Complex Systems and Diseases
5.2. Network Medicine
6. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Lualdi, M.; Alberio, T.; Fasano, M. Proteostasis and Proteotoxicity in the Network Medicine Era. Int. J. Mol. Sci. 2020, 21, 6405. https://doi.org/10.3390/ijms21176405
Lualdi M, Alberio T, Fasano M. Proteostasis and Proteotoxicity in the Network Medicine Era. International Journal of Molecular Sciences. 2020; 21(17):6405. https://doi.org/10.3390/ijms21176405
Chicago/Turabian StyleLualdi, Marta, Tiziana Alberio, and Mauro Fasano. 2020. "Proteostasis and Proteotoxicity in the Network Medicine Era" International Journal of Molecular Sciences 21, no. 17: 6405. https://doi.org/10.3390/ijms21176405
APA StyleLualdi, M., Alberio, T., & Fasano, M. (2020). Proteostasis and Proteotoxicity in the Network Medicine Era. International Journal of Molecular Sciences, 21(17), 6405. https://doi.org/10.3390/ijms21176405