Next Article in Journal
Arctigenin Attenuates Breast Cancer Progression through Decreasing GM-CSF/TSLP/STAT3/β-Catenin Signaling
Previous Article in Journal
Assessing Lysosomal Disorders in the NGS Era: Identification of Novel Rare Variants
Review

Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism

by 1,2,†, 1,2,†, 1,2, 1,2, 1,2,3, 1,2, 1,2, 1,2, 1,2, 1,2, 1,2,* and 1,2,*
1
College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China
2
Farm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China
3
Institute of Animal Husbandry and Veterinary, Guizhou Academy of Agricultural Science, Guiyang 550005, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(17), 6356; https://doi.org/10.3390/ijms21176356
Received: 11 July 2020 / Revised: 20 August 2020 / Accepted: 27 August 2020 / Published: 2 September 2020
(This article belongs to the Section Molecular Biology)
Short-chain fatty acids (SCFAs), particularly acetate, propionate and butyrate, are mainly produced by anaerobic fermentation of gut microbes. SCFAs play an important role in regulating energy metabolism and energy supply, as well as maintaining the homeostasis of the intestinal environment. In recent years, many studies have shown that SCFAs demonstrate physiologically beneficial effects, and the signalling pathways related to SCFA production, absorption, metabolism, and intestinal effects have been discovered. Two major signalling pathways concerning SCFAs, G-protein-coupled receptors (GPRCs) and histone deacetylases (HDACs), are well recognized. In this review, we summarize the recent advances concerning the biological properties of SCFAs and the signalling pathways in inflammation and glucose and lipid metabolism. View Full-Text
Keywords: short-chain fatty acids; inflammation; glycose and lipid metabolism; signalling pathways short-chain fatty acids; inflammation; glycose and lipid metabolism; signalling pathways
Show Figures

Figure 1

MDPI and ACS Style

He, J.; Zhang, P.; Shen, L.; Niu, L.; Tan, Y.; Chen, L.; Zhao, Y.; Bai, L.; Hao, X.; Li, X.; Zhang, S.; Zhu, L. Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism. Int. J. Mol. Sci. 2020, 21, 6356. https://doi.org/10.3390/ijms21176356

AMA Style

He J, Zhang P, Shen L, Niu L, Tan Y, Chen L, Zhao Y, Bai L, Hao X, Li X, Zhang S, Zhu L. Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism. International Journal of Molecular Sciences. 2020; 21(17):6356. https://doi.org/10.3390/ijms21176356

Chicago/Turabian Style

He, Jin, Peiwen Zhang, Linyuan Shen, Lili Niu, Ya Tan, Lei Chen, Ye Zhao, Lin Bai, Xiaoxia Hao, Xuewei Li, Shunhua Zhang, and Li Zhu. 2020. "Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism" International Journal of Molecular Sciences 21, no. 17: 6356. https://doi.org/10.3390/ijms21176356

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop