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Psoriasis and Connective Tissue Diseases
 
 
Review

Oxidative Stress as an Important Contributor to the Pathogenesis of Psoriasis

1
Department of Medical Biology and Genetics, University of Gdańsk, Wita Stwosza 59, 80-308 Gdańsk, Poland
2
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Laboratory of Molecular Biology, Kładki 24, 80-822 Gdańsk, Poland
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(17), 6206; https://doi.org/10.3390/ijms21176206
Received: 31 July 2020 / Revised: 24 August 2020 / Accepted: 25 August 2020 / Published: 27 August 2020
(This article belongs to the Special Issue Psoriasis: Pathogenesis, Comorbidities, and Therapy Updated)
This review discusses how oxidative stress (OS), an imbalance between oxidants and antioxidants in favor of the oxidants, increased production of reactive oxygen species (ROS)/reactive nitrogen species (RNS), and decreased concentration/activity of antioxidants affect the pathogenesis or cause the enhancement of psoriasis (Ps). Here, we also consider how ROS/RNS-induced stress modulates the activity of transcriptional factors and regulates numerous protein kinase cascades that participate in the regulation of crosstalk between autophagy, apoptosis, and regeneration. Answers to these questions will likely uncover novel strategies for the treatment of Ps. Action in the field will avoid destructive effects of ROS/RNS-mediated OS resulting in cellular dysfunction and cell death. The combination of the fragmentary information on the role of OS can provide evidence to extend the full picture of Ps. View Full-Text
Keywords: psoriasis; oxidative stress; reactive oxygen species/reactive nitrogen species; antioxidants psoriasis; oxidative stress; reactive oxygen species/reactive nitrogen species; antioxidants
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MDPI and ACS Style

Pleńkowska, J.; Gabig-Cimińska, M.; Mozolewski, P. Oxidative Stress as an Important Contributor to the Pathogenesis of Psoriasis. Int. J. Mol. Sci. 2020, 21, 6206. https://doi.org/10.3390/ijms21176206

AMA Style

Pleńkowska J, Gabig-Cimińska M, Mozolewski P. Oxidative Stress as an Important Contributor to the Pathogenesis of Psoriasis. International Journal of Molecular Sciences. 2020; 21(17):6206. https://doi.org/10.3390/ijms21176206

Chicago/Turabian Style

Pleńkowska, Joanna, Magdalena Gabig-Cimińska, and Paweł Mozolewski. 2020. "Oxidative Stress as an Important Contributor to the Pathogenesis of Psoriasis" International Journal of Molecular Sciences 21, no. 17: 6206. https://doi.org/10.3390/ijms21176206

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