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Open AccessArticle

Specific Receptors for the Chemokines CXCR2 and CXCR4 in Pancreatic Cancer

1
Department of Neurodegeneration Diagnostics, Medical University of Bialystok, 15-269 Bialystok, Poland
2
Department of Biochemical Diagnostics, Medical University of Bialystok, 15-269 Bialystok, Poland
3
Second Department of General Surgery, Medical University of Bialystok, 15-276 Bialystok, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(17), 6193; https://doi.org/10.3390/ijms21176193
Received: 11 August 2020 / Accepted: 25 August 2020 / Published: 27 August 2020
(This article belongs to the Special Issue Molecular Biomarkers of Selected Diseases of Civilization)
Background: The mortality rate of pancreatic cancer (PC) is equal to its incidence and the majority of PC patients die within a few months of diagnosis. Therefore, a search for new biomarkers useful in the diagnosis and prognosis of PC is ongoing. Objectives: The aim of our study was to compare the utility of CXCR2 and CXCR4 in the diagnosis and prediction of PC with classical tumor marker (carcinoembryonic antigen, CEA) and marker of inflammation–C-reactive protein (CRP). Patients and Methods: The study comprised 64 subjects — 32 PC patients and 32 healthy volunteers. Serum concentrations of tested proteins were analysed using immunological methods. Results: Serum CXCR2 and CXCR4 concentrations, similarly to those of CEA and CRP, were significantly elevated in PC patients compared to healthy controls. Moreover, concentrations of CXCR4 were significantly correlated with CXCR2 and CRP levels, while CRP concentrations were correlated with CXCR2 and CEA levels. The diagnostic sensitivity and the predictive value for negative (PV−ve) results for CXCR4 were similar to those of CEA and higher than those of CXCR2 and CRP, while the area under the ROC curve (AUC) for CXCR4 was the highest among all tested proteins (CXCR2, CEA, CRP). Moreover, serum CXCR2 was found to be a significant predictor of PC risk. Conclusions: CXCR4 is a better candidate for a tumor marker than CXCR2 in the diagnosis of PC, while serum CXCR2 is a significant predictor of PC risk. View Full-Text
Keywords: pancreatic cancer; receptors for chemokines; biomarker pancreatic cancer; receptors for chemokines; biomarker
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MDPI and ACS Style

Litman-Zawadzka, A.; Łukaszewicz-Zając, M.; Gryko, M.; Kulczyńska-Przybik, A.; Kędra, B.; Mroczko, B. Specific Receptors for the Chemokines CXCR2 and CXCR4 in Pancreatic Cancer. Int. J. Mol. Sci. 2020, 21, 6193. https://doi.org/10.3390/ijms21176193

AMA Style

Litman-Zawadzka A, Łukaszewicz-Zając M, Gryko M, Kulczyńska-Przybik A, Kędra B, Mroczko B. Specific Receptors for the Chemokines CXCR2 and CXCR4 in Pancreatic Cancer. International Journal of Molecular Sciences. 2020; 21(17):6193. https://doi.org/10.3390/ijms21176193

Chicago/Turabian Style

Litman-Zawadzka, Ala; Łukaszewicz-Zając, Marta; Gryko, Mariusz; Kulczyńska-Przybik, Agnieszka; Kędra, Bogusław; Mroczko, Barbara. 2020. "Specific Receptors for the Chemokines CXCR2 and CXCR4 in Pancreatic Cancer" Int. J. Mol. Sci. 21, no. 17: 6193. https://doi.org/10.3390/ijms21176193

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