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Review

Drosophila melanogaster Mitochondrial Carriers: Similarities and Differences with the Human Carriers

1
Department of Pharmacy, Health, and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende (Cosenza), Italy
2
Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy
3
Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, 70125 Bari, Italy
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(17), 6052; https://doi.org/10.3390/ijms21176052
Received: 30 July 2020 / Revised: 19 August 2020 / Accepted: 19 August 2020 / Published: 22 August 2020
Mitochondrial carriers are a family of structurally related proteins responsible for the exchange of metabolites, cofactors and nucleotides between the cytoplasm and mitochondrial matrix. The in silico analysis of the Drosophila melanogaster genome has highlighted the presence of 48 genes encoding putative mitochondrial carriers, but only 20 have been functionally characterized. Despite most Drosophila mitochondrial carrier genes having human homologs and sharing with them 50% or higher sequence identity, D. melanogaster genes display peculiar differences from their human counterparts: (1) in the fruit fly, many genes encode more transcript isoforms or are duplicated, resulting in the presence of numerous subfamilies in the genome; (2) the expression of the energy-producing genes in D. melanogaster is coordinated from a motif known as Nuclear Respiratory Gene (NRG), a palindromic 8-bp sequence; (3) fruit-fly duplicated genes encoding mitochondrial carriers show a testis-biased expression pattern, probably in order to keep a duplicate copy in the genome. Here, we review the main features, biological activities and role in the metabolism of the D. melanogaster mitochondrial carriers characterized to date, highlighting similarities and differences with their human counterparts. Such knowledge is very important for obtaining an integrated view of mitochondrial function in D. melanogaster metabolism. View Full-Text
Keywords: membrane transport; mitochondrial carrier; mitochondrial transporter; mitochondrial metabolism; Drosophila melanogaster; mitochondria; SLC25; proteoliposomes membrane transport; mitochondrial carrier; mitochondrial transporter; mitochondrial metabolism; Drosophila melanogaster; mitochondria; SLC25; proteoliposomes
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MDPI and ACS Style

Curcio, R.; Lunetti, P.; Zara, V.; Ferramosca, A.; Marra, F.; Fiermonte, G.; Cappello, A.R.; De Leonardis, F.; Capobianco, L.; Dolce, V. Drosophila melanogaster Mitochondrial Carriers: Similarities and Differences with the Human Carriers. Int. J. Mol. Sci. 2020, 21, 6052. https://doi.org/10.3390/ijms21176052

AMA Style

Curcio R, Lunetti P, Zara V, Ferramosca A, Marra F, Fiermonte G, Cappello AR, De Leonardis F, Capobianco L, Dolce V. Drosophila melanogaster Mitochondrial Carriers: Similarities and Differences with the Human Carriers. International Journal of Molecular Sciences. 2020; 21(17):6052. https://doi.org/10.3390/ijms21176052

Chicago/Turabian Style

Curcio, Rosita, Paola Lunetti, Vincenzo Zara, Alessandra Ferramosca, Federica Marra, Giuseppe Fiermonte, Anna R. Cappello, Francesco De Leonardis, Loredana Capobianco, and Vincenza Dolce. 2020. "Drosophila melanogaster Mitochondrial Carriers: Similarities and Differences with the Human Carriers" International Journal of Molecular Sciences 21, no. 17: 6052. https://doi.org/10.3390/ijms21176052

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