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Open AccessArticle

Controlled Drug Release and Cytotoxicity Studies of Beta-Lapachone and Doxorubicin Loaded into Cyclodextrins Attached to a Polyethyleneimine Matrix

1
Faculty of Chemistry, University of Warsaw, Pasteura 1 Str., PL-02-093 Warsaw, Poland
2
Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3 Str., PL-00-664 Warsaw, Poland
3
Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str., PL-02-097 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(16), 5832; https://doi.org/10.3390/ijms21165832
Received: 14 July 2020 / Revised: 7 August 2020 / Accepted: 12 August 2020 / Published: 14 August 2020
(This article belongs to the Special Issue Recent Insights in Chemistry and Technology of Cyclodextrins)
This work presents a new look at the application of cyclodextrins (CD) as a drug nanocarrier. Two different cyclodextrins (αCD, βCD) were covalently conjugated to branched polyethylenimine (PEI), which was additionally functionalized with folic acid (PEI-βCD-αCD-FA). Here, we demonstrated that the combination of αCD and βCD enabled to load and control release of two anticancer drugs: doxorubicin (DOX) and beta-lapachone (beta-LP) (DOX in β-CD and beta-LP into α-CD) via host-guest inclusion. The PEI-βCD(DOX)-αCD-FA nanoconjugate was used to transport anticancer drugs into A549 lung cancer cells for estimation the cytotoxic and antitumor effect of this nanoconjugate. The presence of FA molecules should facilitate the penetration of studied nanoconjugate into the cell. Whereas, the non-cellular experiments proved that the drugs are released from the carrier mainly in the pH 4.0. The release mechanism is found to be anomalous in all studied cases. View Full-Text
Keywords: controlled drug release; cyclodextrin; lapachone; doxorubicin; polyethylenimine; cytotoxicity studies controlled drug release; cyclodextrin; lapachone; doxorubicin; polyethylenimine; cytotoxicity studies
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Kowalczyk, A.; Kasprzak, A.; Poplawska, M.; Ruzycka, M.; Grudzinski, I.P.; Nowicka, A.M. Controlled Drug Release and Cytotoxicity Studies of Beta-Lapachone and Doxorubicin Loaded into Cyclodextrins Attached to a Polyethyleneimine Matrix. Int. J. Mol. Sci. 2020, 21, 5832.

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