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Review

Preventing Tumour Recurrence after Liver Transplantation: The Role of Machine Perfusion

1
Liver Unit, Albert Einstein Hospital, 05652–900 São Paulo, Brazil
2
Albert Einstein Jewish Institute for Education and Research, 05652–900 São Paulo, Brazil
3
Hepatobiliary Unit, Department of Clinical and Experimental Medicine, University of Florence, AOU Careggi, 50134 Florence, Italy
4
The Liver Unit, Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham B15 2TH, UK
5
NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham B15 2TT, UK
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(16), 5791; https://doi.org/10.3390/ijms21165791
Received: 13 July 2020 / Revised: 31 July 2020 / Accepted: 5 August 2020 / Published: 12 August 2020
(This article belongs to the Special Issue Biological Interfaces in Gastrointestinal Cancer)
Tumour recurrence is currently a hot topic in liver transplantation. The basic mechanisms are increasingly discussed, and, for example, recurrence of hepatocellular carcinoma is often described in pre-injured donor livers, which frequently suffer from significant ischemia/reperfusion injury. This review article highlights the underlying mechanisms and describes the specific tissue milieu required to promote tumour recurrence after liver transplantation. We summarise the current literature in this field and show risk factors that contribute to a pro-tumour-recurrent environment. Finally, the potential role of new machine perfusion technology is discussed, including the most recent data, which demonstrate a protective effect of hypothermic oxygenated perfusion before liver transplantation. View Full-Text
Keywords: ischemia reperfusion injury; mitochondria; hepatocellular carcinoma; cancer recurrence; machine perfusion ischemia reperfusion injury; mitochondria; hepatocellular carcinoma; cancer recurrence; machine perfusion
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MDPI and ACS Style

Boteon, Y.; Flores Carvalho, M.A.; Panconesi, R.; Muiesan, P.; Schlegel, A. Preventing Tumour Recurrence after Liver Transplantation: The Role of Machine Perfusion. Int. J. Mol. Sci. 2020, 21, 5791. https://doi.org/10.3390/ijms21165791

AMA Style

Boteon Y, Flores Carvalho MA, Panconesi R, Muiesan P, Schlegel A. Preventing Tumour Recurrence after Liver Transplantation: The Role of Machine Perfusion. International Journal of Molecular Sciences. 2020; 21(16):5791. https://doi.org/10.3390/ijms21165791

Chicago/Turabian Style

Boteon, Yuri, Mauricio A. Flores Carvalho, Rebecca Panconesi, Paolo Muiesan, and Andrea Schlegel. 2020. "Preventing Tumour Recurrence after Liver Transplantation: The Role of Machine Perfusion" International Journal of Molecular Sciences 21, no. 16: 5791. https://doi.org/10.3390/ijms21165791

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