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Crosstalk between Tumor and Stromal Cells in Pancreatic Ductal Adenocarcinoma

Institute of Physiological Chemistry, University of Ulm, 89081 Ulm, Germany
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(15), 5486; https://doi.org/10.3390/ijms21155486
Received: 25 June 2020 / Revised: 22 July 2020 / Accepted: 29 July 2020 / Published: 31 July 2020
(This article belongs to the Special Issue Biological Interfaces in Gastrointestinal Cancer)
Pancreatic ductal adenocarcinoma (PDAC) remains a lethal cancer. The poor prognosis calls for a more detailed understanding of disease biology in order to pave the way for the development of effective therapies. Typically, the pancreatic tumor is composed of a minority of malignant cells within an excessive tumor microenvironment (TME) consisting of extracellular matrix (ECM), fibroblasts, immune cells, and endothelial cells. Research conducted in recent years has particularly focused on cancer-associated fibroblasts (CAFs) which represent the most prominent cellular component of the desmoplastic stroma. Here, we review the complex crosstalk between CAFs, tumor cells, and other components of the TME, and illustrate how these interactions drive disease progression. We also discuss the emerging field of CAF heterogeneity, their tumor-supportive versus tumor-suppressive capacity, and the consequences for designing stroma-targeted therapies in the future. View Full-Text
Keywords: PDAC; CAF; immune microenvironment; tumor microenvironment; cancer metabolism; CAF heterogeneity PDAC; CAF; immune microenvironment; tumor microenvironment; cancer metabolism; CAF heterogeneity
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MDPI and ACS Style

Sperb, N.; Tsesmelis, M.; Wirth, T. Crosstalk between Tumor and Stromal Cells in Pancreatic Ductal Adenocarcinoma. Int. J. Mol. Sci. 2020, 21, 5486. https://doi.org/10.3390/ijms21155486

AMA Style

Sperb N, Tsesmelis M, Wirth T. Crosstalk between Tumor and Stromal Cells in Pancreatic Ductal Adenocarcinoma. International Journal of Molecular Sciences. 2020; 21(15):5486. https://doi.org/10.3390/ijms21155486

Chicago/Turabian Style

Sperb, Nadine, Miltiadis Tsesmelis, and Thomas Wirth. 2020. "Crosstalk between Tumor and Stromal Cells in Pancreatic Ductal Adenocarcinoma" International Journal of Molecular Sciences 21, no. 15: 5486. https://doi.org/10.3390/ijms21155486

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