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Review

Trans-Axonal Signaling in Neural Circuit Wiring

Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(14), 5170; https://doi.org/10.3390/ijms21145170
Received: 17 June 2020 / Revised: 15 July 2020 / Accepted: 17 July 2020 / Published: 21 July 2020
(This article belongs to the Special Issue Molecular Mechanisms of Neural Circuit Development and Regeneration)
The development of neural circuits is a complex process that relies on the proper navigation of axons through their environment to their appropriate targets. While axon–environment and axon–target interactions have long been known as essential for circuit formation, communication between axons themselves has only more recently emerged as another crucial mechanism. Trans-axonal signaling governs many axonal behaviors, including fasciculation for proper guidance to targets, defasciculation for pathfinding at important choice points, repulsion along and within tracts for pre-target sorting and target selection, repulsion at the target for precise synaptic connectivity, and potentially selective degeneration for circuit refinement. This review outlines the recent advances in identifying the molecular mechanisms of trans-axonal signaling and discusses the role of axon–axon interactions during the different steps of neural circuit formation. View Full-Text
Keywords: axon–axon communication; growth cone; guidance; fasciculation; adhesion; repulsion; axon sorting; topographic maps axon–axon communication; growth cone; guidance; fasciculation; adhesion; repulsion; axon sorting; topographic maps
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MDPI and ACS Style

Spead, O.; Poulain, F.E. Trans-Axonal Signaling in Neural Circuit Wiring. Int. J. Mol. Sci. 2020, 21, 5170. https://doi.org/10.3390/ijms21145170

AMA Style

Spead O, Poulain FE. Trans-Axonal Signaling in Neural Circuit Wiring. International Journal of Molecular Sciences. 2020; 21(14):5170. https://doi.org/10.3390/ijms21145170

Chicago/Turabian Style

Spead, Olivia, and Fabienne E. Poulain 2020. "Trans-Axonal Signaling in Neural Circuit Wiring" International Journal of Molecular Sciences 21, no. 14: 5170. https://doi.org/10.3390/ijms21145170

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