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Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch

by 1,2,*,†, 1,†, 1 and 2,3
1
Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel
2
The Skin Research Institute, The Dead Sea and Arava Science Center, Masada 86910, Israel
3
Ben-Gurion University of the Negev, Eilat Campus, Eilat 8855630, Israel
*
Author to whom correspondence should be addressed.
Contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(14), 4883; https://doi.org/10.3390/ijms21144883
Received: 16 June 2020 / Revised: 7 July 2020 / Accepted: 8 July 2020 / Published: 10 July 2020
(This article belongs to the Section Molecular Biology)
Pruritoceptive (dermal) itch was long considered an accompanying symptom of diseases, a side effect of drug applications, or a temporary sensation induced by invading pruritogens, as produced by the stinging nettle. Due to extensive research in recent years, it was possible to provide detailed insights into the mechanism of itch mediation and modulation. Hence, it became apparent that pruritus is a complex symptom or disease in itself, which requires particular attention to improve patients’ health. Here, we summarize recent findings in pruritoceptive itch, including how this sensation is triggered and modulated by diverse endogenous and exogenous pruritogens and their receptors. A differentiation between mediating pruritogen and modulating pruritogen seems to be of great advantage to understand and decipher the molecular mechanism of itch perception. Only a comprehensive view on itch sensation will provide a solid basis for targeting this long-neglected adverse sensation accompanying numerous diseases and many drug side effects. Finally, we identify critical aspects of itch perception that require future investigation. View Full-Text
Keywords: pruritus; itch; receptors; mediator; modulator; GPCR; interleukin; histamine; non-histaminergic; dermal itch pruritus; itch; receptors; mediator; modulator; GPCR; interleukin; histamine; non-histaminergic; dermal itch
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MDPI and ACS Style

Kahremany, S.; Hofmann, L.; Gruzman, A.; Cohen, G. Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch. Int. J. Mol. Sci. 2020, 21, 4883. https://doi.org/10.3390/ijms21144883

AMA Style

Kahremany S, Hofmann L, Gruzman A, Cohen G. Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch. International Journal of Molecular Sciences. 2020; 21(14):4883. https://doi.org/10.3390/ijms21144883

Chicago/Turabian Style

Kahremany, Shirin, Lukas Hofmann, Arie Gruzman, and Guy Cohen. 2020. "Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch" International Journal of Molecular Sciences 21, no. 14: 4883. https://doi.org/10.3390/ijms21144883

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