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The Role of Deubiquitinating Enzymes in Acute Lung Injury and Acute Respiratory Distress Syndrome

by and *
Division of Pulmonary, Allergy, Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(14), 4842; https://doi.org/10.3390/ijms21144842
Received: 1 June 2020 / Revised: 2 July 2020 / Accepted: 5 July 2020 / Published: 8 July 2020
(This article belongs to the Special Issue Proteolytic Control of Deubiquitinating Enzymes in Health and Disease)
Acute lung injury and acute respiratory distress syndrome (ALI/ARDS) are characterized by an inflammatory response, alveolar edema, and hypoxemia. ARDS occurs most often in the settings of pneumonia, sepsis, aspiration of gastric contents, or severe trauma. The prevalence of ARDS is approximately 10% in patients of intensive care. There is no effective remedy with mortality high at 30–40%. Most functional proteins are dynamic and stringently governed by ubiquitin proteasomal degradation. Protein ubiquitination is reversible, the covalently attached monoubiquitin or polyubiquitin moieties within the targeted protein can be removed by a group of enzymes called deubiquitinating enzymes (DUBs). Deubiquitination plays an important role in the pathobiology of ALI/ARDS as it regulates proteins critical in engagement of the alveolo-capillary barrier and in the inflammatory response. In this review, we provide an overview of how DUBs emerge in pathogen-induced pulmonary inflammation and related aspects in ALI/ARDS. Better understanding of deubiquitination-relatedsignaling may lead to novel therapeutic approaches by targeting specific elements of the deubiquitination pathways. View Full-Text
Keywords: acute lung injury/acute respiratory distress syndrome; deubiquitinating enzyme; protein stability; inflammation; infection acute lung injury/acute respiratory distress syndrome; deubiquitinating enzyme; protein stability; inflammation; infection
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MDPI and ACS Style

Li, T.; Zou, C. The Role of Deubiquitinating Enzymes in Acute Lung Injury and Acute Respiratory Distress Syndrome. Int. J. Mol. Sci. 2020, 21, 4842. https://doi.org/10.3390/ijms21144842

AMA Style

Li T, Zou C. The Role of Deubiquitinating Enzymes in Acute Lung Injury and Acute Respiratory Distress Syndrome. International Journal of Molecular Sciences. 2020; 21(14):4842. https://doi.org/10.3390/ijms21144842

Chicago/Turabian Style

Li, Tiao; Zou, Chunbin. 2020. "The Role of Deubiquitinating Enzymes in Acute Lung Injury and Acute Respiratory Distress Syndrome" Int. J. Mol. Sci. 21, no. 14: 4842. https://doi.org/10.3390/ijms21144842

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