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Open AccessProject Report

The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity

1
Evolutionary Biology Centre, Uppsala University, 75236 Uppsala, Sweden
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Institute of Environmental Medicine, Karolinska Institute, 17177 Stockholm, Sweden
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Department of Toxicology, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
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Faculty of Science and Technology, Umeå University, 90187 Umeå, Sweden
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Department of Health Sciences, Karlstad University, 65188 Karlstad, Sweden
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Evolution of Endocrine Regulations UMR 7221, Centre National de la Recherche Scientifique, 75005 Paris, France
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IUF—Leibniz Research Institute for Environmental Medicine, 40225 Düsseldorf, Germany
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Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
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GREEN Tox GmbH, CH-8057 Zürich, Switzerland
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In Vitro Toxicology and Biomedicine, University of Konstanz, D-78457 Konstanz, Germany
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Department Environment and Health, Vrije University, 1081HV Amsterdam, The Netherlands
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Murdoch Children’s Research Institute, Royal Children’s Hospital, Parkville, Victoria 3052, Australia
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Institute of Environment, Health and Societies, Brunel University London, Uxbridge UB8 3PH, UK
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Department of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, Italy
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Department of Physiology, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain
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Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine, Utrecht University, 3584 CM Utrecht, The Netherlands
17
Sorbonne Université, Inserm, CNRS, ICM-GH Pitié-Salpêtrière, 75651 Paris, France
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(11), 3978; https://doi.org/10.3390/ijms21113978
Received: 30 March 2020 / Revised: 21 May 2020 / Accepted: 28 May 2020 / Published: 1 June 2020
(This article belongs to the Special Issue Advances in the Research of Endocrine Disrupting Chemicals 2.0)
Ubiquitous exposure to endocrine-disrupting chemicals (EDCs) has caused serious concerns about the ability of these chemicals to affect neurodevelopment, among others. Since endocrine disruption (ED)-induced developmental neurotoxicity (DNT) is hardly covered by the chemical testing tools that are currently in regulatory use, the Horizon 2020 research and innovation action ENDpoiNTs has been launched to fill the scientific and methodological gaps related to the assessment of this type of chemical toxicity. The ENDpoiNTs project will generate new knowledge about ED-induced DNT and aims to develop and improve in vitro, in vivo, and in silico models pertaining to ED-linked DNT outcomes for chemical testing. This will be achieved by establishing correlative and causal links between known and novel neurodevelopmental endpoints and endocrine pathways through integration of molecular, cellular, and organismal data from in vitro and in vivo models. Based on this knowledge, the project aims to provide adverse outcome pathways (AOPs) for ED-induced DNT and to develop and integrate new testing tools with high relevance for human health into European and international regulatory frameworks. View Full-Text
Keywords: endocrine-disrupting chemicals; developmental neurotoxicity; chemical testing; adverse outcome pathways endocrine-disrupting chemicals; developmental neurotoxicity; chemical testing; adverse outcome pathways
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Figure 1

MDPI and ACS Style

Lupu, D.; Andersson, P.; Bornehag, C.-G.; Demeneix, B.; Fritsche, E.; Gennings, C.; Lichtensteiger, W.; Leist, M.; Leonards, P.E.G.; Ponsonby, A.-L.; Scholze, M.; Testa, G.; Tresguerres, J.A.F.; Westerink, R.H.S.; Zalc, B.; Rüegg, J. The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity. Int. J. Mol. Sci. 2020, 21, 3978. https://doi.org/10.3390/ijms21113978

AMA Style

Lupu D, Andersson P, Bornehag C-G, Demeneix B, Fritsche E, Gennings C, Lichtensteiger W, Leist M, Leonards PEG, Ponsonby A-L, Scholze M, Testa G, Tresguerres JAF, Westerink RHS, Zalc B, Rüegg J. The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity. International Journal of Molecular Sciences. 2020; 21(11):3978. https://doi.org/10.3390/ijms21113978

Chicago/Turabian Style

Lupu, Diana; Andersson, Patrik; Bornehag, Carl-Gustaf; Demeneix, Barbara; Fritsche, Ellen; Gennings, Chris; Lichtensteiger, Walter; Leist, Marcel; Leonards, Pim E.G.; Ponsonby, Anne-Louise; Scholze, Martin; Testa, Giuseppe; Tresguerres, Jesus A.F.; Westerink, Remco H.S.; Zalc, Bernard; Rüegg, Joëlle. 2020. "The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity" Int. J. Mol. Sci. 21, no. 11: 3978. https://doi.org/10.3390/ijms21113978

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