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Article

Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (Danio rerio)

1
Biomedical Research Center, Qatar University, Doha P.O. Box 2713, Qatar
2
Department of Biomedical Science, College of Health Sciences, Member of QU Health, Qatar University, Doha P.O. Box 2713, Qatar
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Department of Medical, Surgical and Experimental Surgery, University of Sassari, Viale San Pietro 43, 07100 Sassari, Italy
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Department of Medical Laboratory Sciences, College of Health Sciences and Sharjah Institute for Medical Research, University of Sharjah, Sharjah P.O. Box 27272, UAE
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Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43, 07100 Sassari, Italy
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(11), 3838; https://doi.org/10.3390/ijms21113838
Received: 9 May 2020 / Revised: 21 May 2020 / Accepted: 22 May 2020 / Published: 28 May 2020
Despite their wide industrial use, Zinc oxide (ZnO) nanoparticles (NPs) exhibit a high toxic potential while concerns of their health-related risks are still present, urging additional in vivo clarification studies. Oxidative stress is recognized as the primary trigger of NP-associated toxicity, suggesting antioxidants as a promising counteractive approach. Here, we investigated the protective effect of the natural antioxidant resveratrol against ZnO NP-induced toxicity in vivo using the zebrafish model. Our findings demonstrate that resveratrol counteracts ZnO NP-induced zebrafish lethality preventing cardiac morphological and functional damage. NP-induced vascular structural abnormalities during embryonic fish development were significantly counteracted by resveratrol treatment. Mechanistically, we further showed that resveratrol inhibits ROS increase, prevents mitochondrial membrane potential dysfunction, and counteracts cell apoptosis/necrosis elicited by ZnO NP. Overall, our data provide further evidence demonstrating the primary role of oxidative stress in NP-induced damage, and highlight new insights concerning the protective mechanism of antioxidants against nanomaterial toxicity. View Full-Text
Keywords: resveratrol; nanoparticles; ROS; oxidative stress; antioxidants; mitochondria; zebrafish; zinc oxide resveratrol; nanoparticles; ROS; oxidative stress; antioxidants; mitochondria; zebrafish; zinc oxide
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MDPI and ACS Style

Giordo, R.; Nasrallah, G.K.; Al-Jamal, O.; Paliogiannis, P.; Pintus, G. Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (Danio rerio). Int. J. Mol. Sci. 2020, 21, 3838. https://doi.org/10.3390/ijms21113838

AMA Style

Giordo R, Nasrallah GK, Al-Jamal O, Paliogiannis P, Pintus G. Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (Danio rerio). International Journal of Molecular Sciences. 2020; 21(11):3838. https://doi.org/10.3390/ijms21113838

Chicago/Turabian Style

Giordo, Roberta, Gheyath K. Nasrallah, Ola Al-Jamal, Panagiotis Paliogiannis, and Gianfranco Pintus. 2020. "Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (Danio rerio)" International Journal of Molecular Sciences 21, no. 11: 3838. https://doi.org/10.3390/ijms21113838

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