Overview of Mitochondrial E3 Ubiquitin Ligase MITOL/MARCH5 from Molecular Mechanisms to Diseases
Abstract
:1. Introduction
2. Mitochondria and Intracellular Quality Control by MITOL
2.1. Neurodegenerative Diseases
2.2. Innate Immune Response
2.3. Cell Death in Cancer Cells
2.4. Mitophagy
2.5. Aging
3. Regulation of Mitochondrial Dynamics by MITOL
3.1. Mitochondrial Fission
3.2. Mitochondrial Fusion
4. Relation between MITOL and Membrane Bontact Site with the Endoplasmic Reticulum
4.1. Membrane Contact Site with the Endoplasmic Reticulum
4.2. MCS Formation by MITOL
4.3. UPR Regulation by MITOL
5. Discussion
Author Contributions
Funding
Conflicts of Interest
References
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Shiiba, I.; Takeda, K.; Nagashima, S.; Yanagi, S. Overview of Mitochondrial E3 Ubiquitin Ligase MITOL/MARCH5 from Molecular Mechanisms to Diseases. Int. J. Mol. Sci. 2020, 21, 3781. https://doi.org/10.3390/ijms21113781
Shiiba I, Takeda K, Nagashima S, Yanagi S. Overview of Mitochondrial E3 Ubiquitin Ligase MITOL/MARCH5 from Molecular Mechanisms to Diseases. International Journal of Molecular Sciences. 2020; 21(11):3781. https://doi.org/10.3390/ijms21113781
Chicago/Turabian StyleShiiba, Isshin, Keisuke Takeda, Shun Nagashima, and Shigeru Yanagi. 2020. "Overview of Mitochondrial E3 Ubiquitin Ligase MITOL/MARCH5 from Molecular Mechanisms to Diseases" International Journal of Molecular Sciences 21, no. 11: 3781. https://doi.org/10.3390/ijms21113781