Expression of Genes Involved in Axon Guidance: How Much Have We Learned?
Abstract
:1. Introduction
2. Regulation of Local Gene Expression by Guidance Cues and Receptors through RNA Binding Factors
2.1. BDNF Increases the Local Translation of DSCR1.4 mRNA
2.2. Netrin-1 Regulates the Local Translation of β-actin, Dscam, and tctp mRNAs
2.3. Sema3A Enhances Local Translation of fmr1 and the Processing of miRNAs
3. Transcriptional and Post-Transcriptional Regulation of the Expression of Guidance Proteins and Receptors
3.1. The Expression of Guidance Cues and Receptors are Regulated by Different Transcription Factors
3.2. RNA Binding Factors Regulate the Translation of Axon Guidance mRNAs
4. Pathological Relevance
4.1. The Association of Sema5A and Sema3F with Autism
4.2. The Protective Role of Netrin-1 against Alzheimer’s Disease
5. Concluding Remarks
Funding
Conflicts of Interest
References
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Regulated During: | Targeted Genes | Regulating Factors |
---|---|---|
Transcription | netrin-1 | Oct4 [95], Sox2 [95], NuRD [95], dFezf [96] |
DCC | Islet [107], AP-1 [99] | |
sema6a | Nrf2 [116] | |
sema3e | RORα [97] | |
sema3a | SetD5 [119] | |
Post-transcription | neuropilin-1 | Hermes [26], PUM2 [128] |
robo-1 | miR-92 [136] | |
netrin-1 | let-7 [138] | |
DCC | miR-9 [138], miR-218 [139,140] |
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Kim, S.W.; Kim, K.-T. Expression of Genes Involved in Axon Guidance: How Much Have We Learned? Int. J. Mol. Sci. 2020, 21, 3566. https://doi.org/10.3390/ijms21103566
Kim SW, Kim K-T. Expression of Genes Involved in Axon Guidance: How Much Have We Learned? International Journal of Molecular Sciences. 2020; 21(10):3566. https://doi.org/10.3390/ijms21103566
Chicago/Turabian StyleKim, Sung Wook, and Kyong-Tai Kim. 2020. "Expression of Genes Involved in Axon Guidance: How Much Have We Learned?" International Journal of Molecular Sciences 21, no. 10: 3566. https://doi.org/10.3390/ijms21103566