Next Article in Journal
Complete Mitochondrial Genomes of Two Toxin-Accumulated Nassariids (Neogastropoda: Nassariidae: Nassarius) and Their Implication for Phylogeny
Next Article in Special Issue
A Sphingosine 1-Phosphate Gradient Is Linked to the Cerebral Recruitment of T Helper and Regulatory T Helper Cells during Acute Ischemic Stroke
Previous Article in Journal
PHLD Class Proteins: A Family of New Players in the p53 Network
Previous Article in Special Issue
Sorafenib Treatment and Modulation of the Sphingolipid Pathway Affect Proliferation and Viability of Hepatocellular Carcinoma In Vitro
Review

The Role of Lipid Metabolism in COVID-19 Virus Infection and as a Drug Target

1
Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, 15462 Dasman, Kuwait
2
Department of Genetic and Bioinformatics, Dasman Diabetes Institute, 15462 Dasman, Kuwait
3
Pharmacology and Therapeutics Department, Faculty of Pharmacy, Kuwait University, 13110 Kuwait City, Kuwait
4
Department of Medical Microbiology and Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah 11633, Saudi Arabia
5
Vaccines and Immunotherapy Unit, King Fahd Medical Research Centre, King Abdulaziz University, Jeddah 80205, Saudi Arabia
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(10), 3544; https://doi.org/10.3390/ijms21103544
Received: 21 April 2020 / Revised: 8 May 2020 / Accepted: 8 May 2020 / Published: 17 May 2020
(This article belongs to the Collection Sphingolipid Signaling in Health and Disease)
The current Coronavirus disease 2019 or COVID-19 pandemic has infected over two million people and resulted in the death of over one hundred thousand people at the time of writing this review. The disease is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Even though multiple vaccines and treatments are under development so far, the disease is only slowing down under extreme social distancing measures that are difficult to maintain. SARS-COV-2 is an enveloped virus that is surrounded by a lipid bilayer. Lipids are fundamental cell components that play various biological roles ranging from being a structural building block to a signaling molecule as well as a central energy store. The role lipids play in viral infection involves the fusion of the viral membrane to the host cell, viral replication, and viral endocytosis and exocytosis. Since lipids play a crucial function in the viral life cycle, we asked whether drugs targeting lipid metabolism, such as statins, can be utilized against SARS-CoV-2 and other viruses. In this review, we discuss the role of lipid metabolism in viral infection as well as the possibility of targeting lipid metabolism to interfere with the viral life cycle. View Full-Text
Keywords: coronavirus; COVID-19; SARS-COV-2; lipid metabolism; sphingolipid; endocytosis coronavirus; COVID-19; SARS-COV-2; lipid metabolism; sphingolipid; endocytosis
Show Figures

Figure 1

MDPI and ACS Style

Abu-Farha, M.; Thanaraj, T.A.; Qaddoumi, M.G.; Hashem, A.; Abubaker, J.; Al-Mulla, F. The Role of Lipid Metabolism in COVID-19 Virus Infection and as a Drug Target. Int. J. Mol. Sci. 2020, 21, 3544. https://doi.org/10.3390/ijms21103544

AMA Style

Abu-Farha M, Thanaraj TA, Qaddoumi MG, Hashem A, Abubaker J, Al-Mulla F. The Role of Lipid Metabolism in COVID-19 Virus Infection and as a Drug Target. International Journal of Molecular Sciences. 2020; 21(10):3544. https://doi.org/10.3390/ijms21103544

Chicago/Turabian Style

Abu-Farha, Mohamed, Thangavel A. Thanaraj, Mohammad G. Qaddoumi, Anwar Hashem, Jehad Abubaker, and Fahd Al-Mulla. 2020. "The Role of Lipid Metabolism in COVID-19 Virus Infection and as a Drug Target" International Journal of Molecular Sciences 21, no. 10: 3544. https://doi.org/10.3390/ijms21103544

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop