Next Article in Journal
Cholic Acid Stimulates MMP-9 in Human Colon Cancer Cells via Activation of MAPK, AP-1, and NF-κB Activity
Next Article in Special Issue
The Role of Transforming Growth Factor-Beta in Retinal Ganglion Cells with Hyperglycemia and Oxidative Stress
Previous Article in Journal
Unexpected Impact of a Hepatitis C Virus Inhibitor on 17β-Estradiol Signaling in Breast Cancer
 
 
Article

Mangiferin Alleviates Ovalbumin-Induced Allergic Rhinitis via Nrf2/HO-1/NF-κB Signaling Pathways

1
Department of Anatomy, Jeonbuk National University Medical School, Jeounju, Jeonbuk 54896, Korea
2
Institute for Medical Sciences, Jeonbuk National University, Jeounju, Jeonbuk 54896, Korea
3
Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju, Jeonbuk 54896, Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(10), 3415; https://doi.org/10.3390/ijms21103415
Received: 7 April 2020 / Revised: 6 May 2020 / Accepted: 11 May 2020 / Published: 12 May 2020
(This article belongs to the Special Issue Cellular Models of Oxidative Stress)
Mangiferin (MF), extracted from mango trees, is considered to have anti-inflammatory, anti-apoptotic, and antioxidant effects. However, its effects on allergic rhinitis (AR), remain unclear. We investigated the mechanisms underlying the protective action of MF in ovalbumin (OVA)-induced AR models. AR was induced by OVA challenge in BALB/c mice. Prior to this, MF and dexamethasone were administered. Mice were examined for nasal mucosal inflammation, the generation of allergen-specific cytokine response, and histopathological changes in the nasal mucosa and lung tissue. MF ameliorated nasal symptoms and nasal mucosa inflammation in OVA-induced AR and reduced inflammatory cell infiltration and epithelial disruption in these tissues. MF inhibited the overproduction of Th2/Th17 cytokines and transcription factors. MF downregulated the HO-1/Nrf2 pathways, reduced oxidative stress biomarker levels, and the NF-κB signaling pathways were inhibited. MF exerts protective effects in AR by inhibiting NF-κB and activating HO-1/Nrf2 pathways. MF could be used for the treatment of AR. View Full-Text
Keywords: Mangiferin; allergic rhinitis; inflammation; HO-1/Nrf2 pathway; NF-κB; oxidative stress Mangiferin; allergic rhinitis; inflammation; HO-1/Nrf2 pathway; NF-κB; oxidative stress
Show Figures

Graphical abstract

MDPI and ACS Style

Piao, C.H.; Fan, Y.J.; Nguyen, T.V.; Song, C.H.; Chai, O.H. Mangiferin Alleviates Ovalbumin-Induced Allergic Rhinitis via Nrf2/HO-1/NF-κB Signaling Pathways. Int. J. Mol. Sci. 2020, 21, 3415. https://doi.org/10.3390/ijms21103415

AMA Style

Piao CH, Fan YJ, Nguyen TV, Song CH, Chai OH. Mangiferin Alleviates Ovalbumin-Induced Allergic Rhinitis via Nrf2/HO-1/NF-κB Signaling Pathways. International Journal of Molecular Sciences. 2020; 21(10):3415. https://doi.org/10.3390/ijms21103415

Chicago/Turabian Style

Piao, Chun Hua, Yan Jing Fan, Thi Van Nguyen, Chang Ho Song, and Ok Hee Chai. 2020. "Mangiferin Alleviates Ovalbumin-Induced Allergic Rhinitis via Nrf2/HO-1/NF-κB Signaling Pathways" International Journal of Molecular Sciences 21, no. 10: 3415. https://doi.org/10.3390/ijms21103415

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop