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Open AccessReview

Lipopolysaccharide-Induced Neuroinflammation as a Bridge to Understand Neurodegeneration

1
Department of Pharmacology, Universidade Federal de Minas Gerais, Av. Antonio Carlos 6627, Belo Horizonte 31270-901, Brazil
2
Department of Neuroscience, University of Florida, Gainesville, FL 32610, USA
3
Neuroimmunology and Neurochemistry Research Group, Department of Psychiatry and Psychotherapy, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, D-79104 Freiburg, Germany
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(9), 2293; https://doi.org/10.3390/ijms20092293
Received: 4 April 2019 / Revised: 3 May 2019 / Accepted: 5 May 2019 / Published: 9 May 2019
(This article belongs to the Special Issue Lipopolysaccharides (LPSs) 2018)
A large body of experimental evidence suggests that neuroinflammation is a key pathological event triggering and perpetuating the neurodegenerative process associated with many neurological diseases. Therefore, different stimuli, such as lipopolysaccharide (LPS), are used to model neuroinflammation associated with neurodegeneration. By acting at its receptors, LPS activates various intracellular molecules, which alter the expression of a plethora of inflammatory mediators. These factors, in turn, initiate or contribute to the development of neurodegenerative processes. Therefore, LPS is an important tool for the study of neuroinflammation associated with neurodegenerative diseases. However, the serotype, route of administration, and number of injections of this toxin induce varied pathological responses. Thus, here, we review the use of LPS in various models of neurodegeneration as well as discuss the neuroinflammatory mechanisms induced by this toxin that could underpin the pathological events linked to the neurodegenerative process. View Full-Text
Keywords: lipopolysaccharide; inflammation; neurodegeneration; Alzheimer’s disease; Parkinson’s disease; amyotrophic lateral sclerosis; Huntington’s disease lipopolysaccharide; inflammation; neurodegeneration; Alzheimer’s disease; Parkinson’s disease; amyotrophic lateral sclerosis; Huntington’s disease
MDPI and ACS Style

Batista, C.R.A.; Gomes, G.F.; Candelario-Jalil, E.; Fiebich, B.L.; de Oliveira, A.C.P. Lipopolysaccharide-Induced Neuroinflammation as a Bridge to Understand Neurodegeneration. Int. J. Mol. Sci. 2019, 20, 2293. https://doi.org/10.3390/ijms20092293

AMA Style

Batista CRA, Gomes GF, Candelario-Jalil E, Fiebich BL, de Oliveira ACP. Lipopolysaccharide-Induced Neuroinflammation as a Bridge to Understand Neurodegeneration. International Journal of Molecular Sciences. 2019; 20(9):2293. https://doi.org/10.3390/ijms20092293

Chicago/Turabian Style

Batista, Carla R.A.; Gomes, Giovanni F.; Candelario-Jalil, Eduardo; Fiebich, Bernd L.; de Oliveira, Antonio C.P. 2019. "Lipopolysaccharide-Induced Neuroinflammation as a Bridge to Understand Neurodegeneration" Int. J. Mol. Sci. 20, no. 9: 2293. https://doi.org/10.3390/ijms20092293

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