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Immunoepigenetics Combination Therapies: An Overview of the Role of HDACs in Cancer Immunotherapy

Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, 800 22nd St NW, Suite 8880, Washington, DC 20052, USA
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Int. J. Mol. Sci. 2019, 20(9), 2241; https://doi.org/10.3390/ijms20092241
Received: 22 March 2019 / Revised: 23 April 2019 / Accepted: 28 April 2019 / Published: 7 May 2019
(This article belongs to the Special Issue Histone Deacetylase Inhibitors in Health and Disease)
Long-standing efforts to identify the multifaceted roles of histone deacetylase inhibitors (HDACis) have positioned these agents as promising drug candidates in combatting cancer, autoimmune, neurodegenerative, and infectious diseases. The same has also encouraged the evaluation of multiple HDACi candidates in preclinical studies in cancer and other diseases as well as the FDA-approval towards clinical use for specific agents. In this review, we have discussed how the efficacy of immunotherapy can be leveraged by combining it with HDACis. We have also included a brief overview of the classification of HDACis as well as their various roles in physiological and pathophysiological scenarios to target key cellular processes promoting the initiation, establishment, and progression of cancer. Given the critical role of the tumor microenvironment (TME) towards the outcome of anticancer therapies, we have also discussed the effect of HDACis on different components of the TME. We then have gradually progressed into examples of specific pan-HDACis, class I HDACi, and selective HDACis that either have been incorporated into clinical trials or show promising preclinical effects for future consideration. Finally, we have included examples of ongoing trials for each of the above categories of HDACis as standalone agents or in combination with immunotherapeutic approaches. View Full-Text
Keywords: histone deacetylases; immunotherapy; cancer; combination therapies histone deacetylases; immunotherapy; cancer; combination therapies
MDPI and ACS Style

Banik, D.; Moufarrij, S.; Villagra, A. Immunoepigenetics Combination Therapies: An Overview of the Role of HDACs in Cancer Immunotherapy. Int. J. Mol. Sci. 2019, 20, 2241.

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