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Amniotic Fluid Cells, Stem Cells, and p53: Can We Stereotype p53 Functions?

1
Department of Psychological, Health and Territorial Sciences, Laboratory of Molecular Genetics, School of Medicine and Health Sciences, G. d’ Annunzio University, Chieti-Pescara, 66013 Chieti, Italy
2
Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, P.O. Box 3640, 76021 Karlsruhe, Germany
3
Centre of Aging Science and Translational Medicine (Ce.S.I.-Me.T.), G. d’Annunzio University, Chieti-Pescara, 66013 Chieti, Italy
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(9), 2236; https://doi.org/10.3390/ijms20092236
Received: 1 March 2019 / Revised: 20 April 2019 / Accepted: 30 April 2019 / Published: 7 May 2019
(This article belongs to the Special Issue p53 in Cancer and beyond—40 Years after Its Discovery)
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Abstract

In recent years, great interest has been devoted to finding alternative sources for human stem cells which can be easily isolated, ideally without raising ethical objections. These stem cells should furthermore have a high proliferation rate and the ability to differentiate into all three germ layers. Amniotic fluid, ordinarily discarded as medical waste, is potentially such a novel source of stem cells, and these amniotic fluid derived stem cells are currently gaining a lot of attention. However, further information will be required about the properties of these cells before they can be used for therapeutic purposes. For example, the risk of tumor formation after cell transplantation needs to be explored. The tumor suppressor protein p53, well known for its activity in controlling Cell Prolif.eration and cell death in differentiated cells, has more recently been found to be also active in amniotic fluid stem cells. In this review, we summarize the major findings about human amniotic fluid stem cells since their discovery, followed by a brief overview of the important role played by p53 in embryonic and adult stem cells. In addition, we explore what is known about p53 in amniotic fluid stem cells to date, and emphasize the need to investigate its role, particularly in the context of cell tumorigenicity. View Full-Text
Keywords: amniotic fluid cells; embryonic stem cells; mesenchymal stem cells; p53; proliferation; differentiation amniotic fluid cells; embryonic stem cells; mesenchymal stem cells; p53; proliferation; differentiation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Rodrigues, M.; Blattner, C.; Stuppia, L. Amniotic Fluid Cells, Stem Cells, and p53: Can We Stereotype p53 Functions? Int. J. Mol. Sci. 2019, 20, 2236.

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