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Alternative Splicing in Angiogenesis

Institute of Biomedical and Clinical Sciences, Medical School, College of Medicine and Health, University of Exeter, Exeter EX4 4PY, UK
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(9), 2067; https://doi.org/10.3390/ijms20092067
Received: 26 March 2019 / Revised: 15 April 2019 / Accepted: 23 April 2019 / Published: 26 April 2019
(This article belongs to the Special Issue Pre-mRNA Splicing 2018)
Alternative splicing of pre-mRNA allows the generation of multiple splice isoforms from a given gene, which can have distinct functions. In fact, splice isoforms can have opposing functions and there are many instances whereby a splice isoform acts as an inhibitor of canonical isoform function, thereby adding an additional layer of regulation to important processes. Angiogenesis is an important process that is governed by alternative splicing mechanisms. This review focuses on the alternative spliced isoforms of key genes that are involved in the angiogenesis process; VEGF-A, VEGFR1, VEGFR2, NRP-1, FGFRs, Vasohibin-1, Vasohibin-2, HIF-1α, Angiopoietin-1 and Angiopoietin-2. View Full-Text
Keywords: alternative splicing; angiogenesis; VEGF; VEGFR; NRP; FGFR; vasohibin; HIF-1; angiopoietin alternative splicing; angiogenesis; VEGF; VEGFR; NRP; FGFR; vasohibin; HIF-1; angiopoietin
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MDPI and ACS Style

Bowler, E.; Oltean, S. Alternative Splicing in Angiogenesis. Int. J. Mol. Sci. 2019, 20, 2067. https://doi.org/10.3390/ijms20092067

AMA Style

Bowler E, Oltean S. Alternative Splicing in Angiogenesis. International Journal of Molecular Sciences. 2019; 20(9):2067. https://doi.org/10.3390/ijms20092067

Chicago/Turabian Style

Bowler, Elizabeth, and Sebastian Oltean. 2019. "Alternative Splicing in Angiogenesis" International Journal of Molecular Sciences 20, no. 9: 2067. https://doi.org/10.3390/ijms20092067

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