Next Article in Journal
Gold Nanoparticles for Qualitative Detection of Deltamethrin and Carbofuran Residues in Soil by Surface Enhanced Raman Scattering (SERS)
Next Article in Special Issue
Mechanical Ventilation Impairs IL-17 Cytokine Family Expression in Ventilator-Associated Pneumonia
Previous Article in Journal
Prophylactic Ketamine Treatment Promotes Resilience to Chronic Stress and Accelerates Recovery: Correlation with Changes in Synaptic Plasticity in the CA3 Subregion of the Hippocampus

Understanding Platelets in Infectious and Allergic Lung Diseases

Institute of Applied Molecular Medicine, Department of Basic Medical Sciences, Faculty of Medicine, San Pablo CEU University, 28668 Madrid, Spain
Research Laboratory, Allergy Unit, University Hospital of Malaga-IBIMA, 29010 Malaga, Spain
Blood Transfusion & Non-Transfusional Hemotherapy Unit, University Hospital Puerta de Hierro-Majadahonda, 28220 Madrid, Spain
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(7), 1730;
Received: 11 March 2019 / Revised: 2 April 2019 / Accepted: 5 April 2019 / Published: 8 April 2019
(This article belongs to the Special Issue Lung Diseases and Infections in the New Era)
Emerging evidence suggests that platelets, cytoplasmic fragments derived from megakaryocytes, can no longer be considered just as mediators in hemostasis and coagulation processes, but as key modulators of immunity. Platelets have received increasing attention as the emergence of new methodologies has allowed the characterization of their components and functions in the immune continuum. Platelet activation in infectious and allergic lung diseases has been well documented and associated with bacterial infections reproduced in several animal models of pulmonary bacterial infections. Direct interactions between platelets and bacteria have been associated with increased pulmonary platelet accumulation, whereas bacterial-derived toxins have also been reported to modulate platelet function. Recently, platelets have been found extravascular in the lungs of patients with asthma, and in animal models of allergic lung inflammation. Their ability to interact with immune and endothelial cells and secrete immune mediators makes them one attractive target for biomarker identification that will help characterize their contribution to lung diseases. Here, we present an original review of the last advances in the platelet field with a focus on the contribution of platelets to respiratory infections and allergic-mediated diseases. View Full-Text
Keywords: platelets; mediators; allergic inflammation; infectious disease platelets; mediators; allergic inflammation; infectious disease
Show Figures

Figure 1

MDPI and ACS Style

Gomez-Casado, C.; Villaseñor, A.; Rodriguez-Nogales, A.; Bueno, J.L.; Barber, D.; Escribese, M.M. Understanding Platelets in Infectious and Allergic Lung Diseases. Int. J. Mol. Sci. 2019, 20, 1730.

AMA Style

Gomez-Casado C, Villaseñor A, Rodriguez-Nogales A, Bueno JL, Barber D, Escribese MM. Understanding Platelets in Infectious and Allergic Lung Diseases. International Journal of Molecular Sciences. 2019; 20(7):1730.

Chicago/Turabian Style

Gomez-Casado, Cristina, Alma Villaseñor, Alba Rodriguez-Nogales, Jose L. Bueno, Domingo Barber, and Maria M. Escribese. 2019. "Understanding Platelets in Infectious and Allergic Lung Diseases" International Journal of Molecular Sciences 20, no. 7: 1730.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop