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Neurotensin Receptor-1 Expression in Human Prostate Cancer: A Pilot Study on Primary Tumors and Lymph Node Metastases

1
CNRS, INCIA, UMR 5287, F-33000 Bordeaux, France
2
University of Bordeaux, INCIA, UMR 5287, F-33000 Bordeaux, France
3
Department of Nuclear Medicine, University Hospital of Bordeaux, F-33000 Bordeaux, France
4
Department of Pathology, University Hospital of Martinique, 97261 Fort de France, France
5
Surgical Pathology unit, Department of BioPathology, Institut Bergonié, F-33076 Bordeaux, France
6
INSERM, ACTION U1218, F-33076 Bordeaux, France
7
Department of Urology, University Hospital of Toulouse, F-31000 Toulouse, France
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(7), 1721; https://doi.org/10.3390/ijms20071721
Received: 1 March 2019 / Revised: 27 March 2019 / Accepted: 1 April 2019 / Published: 7 April 2019
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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Abstract

Neurotensin and its high-affinity receptor, NTR1, are involved in the growth of various tumors. Few data are available regarding NTR1 expression in normal and tumoral human prostate tissue samples. NTR1 expression was assessed using immunohistochemistry in 12 normal prostate tissues, 11 benign prostatic hyperplasia (BPH), 44 prostate cancers, and 15 related metastatic lymph nodes (one per patient, when available). NTR1-staining was negative in normal prostate and BPH samples. NTR1 was overexpressed in four out of 44 (9.1%) primary tumors. There was no clear association between NTR1 overexpression and age, PSA-values, Gleason score, pT-status, nodal-status, or margin. NTR1 was expressed at a high level of five out of 15 (33.3%) metastatic lymph nodes. NTR1 overexpression was thus more frequent in metastatic lymph nodes than in primary tumors (p = 0.038). In this limited series of samples, NTR1 overexpression was observed in few primary prostate cancers. Upregulation was more frequent in related lymph nodes. The presence of this target in metastatic lymph nodes may open new perspectives for imaging and radionuclide therapy of prostate cancer. Factors driving NTR1 expression in primary prostate cancer and in nodal and distant metastases still need to be characterized. View Full-Text
Keywords: neurotensin receptor-1; NTR1; prostate cancer; neuropeptide neurotensin receptor-1; NTR1; prostate cancer; neuropeptide
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Morgat, C.; Chastel, A.; Molinie, V.; Schollhammer, R.; Macgrogan, G.; Vélasco, V.; Malavaud, B.; Fernandez, P.; Hindié, E. Neurotensin Receptor-1 Expression in Human Prostate Cancer: A Pilot Study on Primary Tumors and Lymph Node Metastases. Int. J. Mol. Sci. 2019, 20, 1721.

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