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Review

Kidney Lipidomics by Mass Spectrometry Imaging: A Focus on the Glomerulus

1
Lebanese Atomic Energy Commission, NCSR, Beirut 11-8281, Lebanon
2
Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Univ. Paris-Sud, Université Paris-Saclay, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France
3
Institut Mondor de Recherche Biomédicale, INSERM, U955 EQ21, 8, rue du Général Sarrail, 94010 Créteil, France
4
Université Paris Est Créteil, 61, avenue du Général de Gaulle, 94010 Créteil, France
5
Hôpital Henri Mondor, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France
6
Laboratoire d’Archéologie Moléculaire et Structurale, LAMS UMR8220, CNRS, Sorbonne Université, 4 place Jussieu, 75005 Paris, France
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(7), 1623; https://doi.org/10.3390/ijms20071623
Received: 27 February 2019 / Revised: 22 March 2019 / Accepted: 28 March 2019 / Published: 1 April 2019
(This article belongs to the Special Issue Bioactive Lipids and Lipidomics 2018)
Lipid disorders have been associated with glomerulopathies, a distinct type of renal pathologies, such as nephrotic syndrome. Global analyses targeting kidney lipids in this pathophysiologic context have been extensively performed, but most often regardless of the architectural and functional complexity of the kidney. The new developments in mass spectrometry imaging technologies have opened a promising field in localized lipidomic studies focused on this organ. In this article, we revisit the main works having employed the Matrix Assisted Laser Desorption Ionization Time of Flight (MALDI-TOF) technology, and the few reports on the use of TOF-Secondary Ion Mass Spectrometry (TOF-SIMS). We also present a first analysis of mouse kidney cortex sections by cluster TOF-SIMS. The latter represents a good option for high resolution lipid imaging when frozen unfixed histological samples are available. The advantages and drawbacks of this developing field are discussed. View Full-Text
Keywords: MALDI-TOF; TOF-SIMS; glomerulopathies; nephrotic syndrome; MSI MALDI-TOF; TOF-SIMS; glomerulopathies; nephrotic syndrome; MSI
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MDPI and ACS Style

Abbas, I.; Noun, M.; Touboul, D.; Sahali, D.; Brunelle, A.; Ollero, M. Kidney Lipidomics by Mass Spectrometry Imaging: A Focus on the Glomerulus. Int. J. Mol. Sci. 2019, 20, 1623. https://doi.org/10.3390/ijms20071623

AMA Style

Abbas I, Noun M, Touboul D, Sahali D, Brunelle A, Ollero M. Kidney Lipidomics by Mass Spectrometry Imaging: A Focus on the Glomerulus. International Journal of Molecular Sciences. 2019; 20(7):1623. https://doi.org/10.3390/ijms20071623

Chicago/Turabian Style

Abbas, Imane, Manale Noun, David Touboul, Dil Sahali, Alain Brunelle, and Mario Ollero. 2019. "Kidney Lipidomics by Mass Spectrometry Imaging: A Focus on the Glomerulus" International Journal of Molecular Sciences 20, no. 7: 1623. https://doi.org/10.3390/ijms20071623

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