Next Article in Journal
Transcriptome Analysis Reveals Cotton (Gossypium hirsutum) Genes That Are Differentially Expressed in Cadmium Stress Tolerance
Next Article in Special Issue
Dose-Dependent Effect of Hyperbaric Oxygen Treatment on Burn-Induced Neuropathic Pain in Rats
Previous Article in Journal
Curcumin: A Potent Protectant against Esophageal and Gastric Disorders
Previous Article in Special Issue
Administration of Oxygen Ultra-Fine Bubbles Improves Nerve Dysfunction in a Rat Sciatic Nerve Crush Injury Model
Article Menu
Issue 6 (March-2) cover image

Export Article

Open AccessReview

Polyethylene Glycol: The Future of Posttraumatic Nerve Repair? Systemic Review

1
Laboratory of Centre for Preclinical Research, Department of Research Methodology, Medical University of Warsaw, Banacha 1B, 02-091 Warsaw, Poland
2
Timeless Plastic Surgery Clinic, gen. Romana Abrahama 18/322, 03-982 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(6), 1478; https://doi.org/10.3390/ijms20061478
Received: 1 March 2019 / Revised: 18 March 2019 / Accepted: 22 March 2019 / Published: 24 March 2019
(This article belongs to the Special Issue Neuroprotective Strategies 2019)
  |  
PDF [1018 KB, uploaded 24 March 2019]
  |     |  

Abstract

Peripheral nerve injury is a common posttraumatic complication. The precise surgical repair of nerve lesion does not always guarantee satisfactory motor and sensory function recovery. Therefore, enhancement of the regeneration process is a subject of many research strategies. It is believed that polyethylene glycol (PEG) mediates axolemmal fusion, thus enabling the direct restoration of axon continuity. It also inhibits Wallerian degeneration and recovers nerve conduction. This systemic review, performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, describes and summarizes published studies on PEG treatment efficiency in various nerve injury types and repair techniques. Sixteen original experimental studies in animal models and one in humans were analyzed. PEG treatment superiority was reported in almost all experiments (based on favorable electrophysiological, histological, or behavioral results). To date, only one study attempted to transfer the procedure into the clinical phase. However, some technical aspects, e.g., the maximal delay between trauma and successful treatment, await determination. PEG therapy is a promising prospect that may improve the surgical treatment of peripheral nerve injuries in the clinical practice. View Full-Text
Keywords: polyethylene glycol; nerve injury; treatment; review polyethylene glycol; nerve injury; treatment; review
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Paskal, A.M.; Paskal, W.; Pietruski, P.; Wlodarski, P.K. Polyethylene Glycol: The Future of Posttraumatic Nerve Repair? Systemic Review. Int. J. Mol. Sci. 2019, 20, 1478.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top