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Zebrafish Models of Neurodevelopmental Disorders: Limitations and Benefits of Current Tools and Techniques

1
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden
2
Laboratory of Molecular and Cellular Cardiology, Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, 5000 Odense, Denmark
3
Novo Nordisk Foundation for Stem Cell Biology (Danstem), University of Copenhagen, 2200 Copenhagen, Denmark
4
Department of Molecular Medicine and Surgery, Center for Molecular Medicine and Clinical Genetics, Karolinska University Laboratory, Karolinska University Hospital, 171 76 Stockholm, Sweden
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(6), 1296; https://doi.org/10.3390/ijms20061296
Received: 29 January 2019 / Revised: 26 February 2019 / Accepted: 11 March 2019 / Published: 14 March 2019
(This article belongs to the Special Issue Zebrafish 2.0: A Model for Toxicological Research)
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Abstract

For the past few years there has been an exponential increase in the use of animal models to confirm the pathogenicity of candidate disease-causing genetic variants found in patients. One such animal model is the zebrafish. Despite being a non-mammalian animal, the zebrafish model has proven its potential in recapitulating the phenotypes of many different human genetic disorders. This review will focus on recent advances in the modeling of neurodevelopmental disorders in zebrafish, covering aspects from early brain development to techniques used for modulating gene expression, as well as how to best characterize the resulting phenotypes. We also review other existing models of neurodevelopmental disorders, and the current efforts in developing and testing compounds with potential therapeutic value. View Full-Text
Keywords: zebrafish; neurodevelopmental disorders; disease models; functional assays zebrafish; neurodevelopmental disorders; disease models; functional assays
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Vaz, R.; Hofmeister, W.; Lindstrand, A. Zebrafish Models of Neurodevelopmental Disorders: Limitations and Benefits of Current Tools and Techniques. Int. J. Mol. Sci. 2019, 20, 1296.

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