Next Article in Journal
Combining Mechanochemistry and Spray Congealing for New Praziquantel Pediatric Formulations in Schistosomiasis Treatment
Previous Article in Journal
Pharmacokinetic and Metabolomic Studies with BIO 300, a Nanosuspension of Genistein, in a Nonhuman Primate Model
Article Menu
Issue 5 (March-1) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2019, 20(5), 1232; https://doi.org/10.3390/ijms20051232

Potential Functions of the Gastrointestinal Microbiome Inhabiting the Length of the Rat Digest Tract

1,2, 1,2,*, 1,2, 1,2,3 and 1,2,3,4
1
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China
2
School of Food Science and Technology, Jiangnan University, Wuxi 214122, China
3
National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, China
4
Beijing Innovation Center of Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing 100048, China
*
Author to whom correspondence should be addressed.
Received: 13 February 2019 / Revised: 4 March 2019 / Accepted: 8 March 2019 / Published: 12 March 2019
(This article belongs to the Section Molecular Microbiology)
  |  
PDF [1389 KB, uploaded 12 March 2019]
  |     |  

Abstract

The rat is an important model animal used frequently in biological researches exploring the correlations between gut microbiome and a wide array of diseases. In this study, we used an extended ancestral-state reconstruction algorithm to predict the functional capabilities of the rat gastrointestinal microbiome. Our results indicate an apparent tendency toward metabolic heterogeneity along the longitudinal and transverse axes of the rat gastrointestinal tract (GIT). This heterogeneity was suggested by the enriched small-molecule transport activity and amino acid metabolism in the upper GIT, the aerobic energy metabolism in the stomach and the mucolysis-related metabolism in the lower GIT mucus layer. In contrast to prior results, many functional overlaps were observed when the gastrointestinal microbiomes of different hosts were compared. These overlaps implied that although both the biogeographic location and host genotype were prominent driving forces in shaping the gastrointestinal microbiota, the microbiome functions were similar across hosts when observed under similar physicochemical conditions at identical anatomical sites. Our work effectively complements the rat microbial biogeography dataset we released in 2017 and, thus, contributes to a better understanding and prediction of disease-related alterations in microbial community function. View Full-Text
Keywords: rat; gastrointestinal tract; microbiome function; ecosystem service rat; gastrointestinal tract; microbiome function; ecosystem service
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Li, D.; Chen, H.; Zhao, J.; Zhang, H.; Chen, W. Potential Functions of the Gastrointestinal Microbiome Inhabiting the Length of the Rat Digest Tract. Int. J. Mol. Sci. 2019, 20, 1232.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top