Emerging Role of Eukaryote Ribosomes in Translational Control
AbstractTranslation is one of the final steps that regulate gene expression. The ribosome is the effector of translation through to its role in mRNA decoding and protein synthesis. Many mechanisms have been extensively described accounting for translational regulation. However it emerged only recently that ribosomes themselves could contribute to this regulation. Indeed, though it is well-known that the translational efficiency of the cell is linked to ribosome abundance, studies recently demonstrated that the composition of the ribosome could alter translation of specific mRNAs. Evidences suggest that according to the status, environment, development, or pathological conditions, cells produce different populations of ribosomes which differ in their ribosomal protein and/or RNA composition. Those observations gave rise to the concept of “specialized ribosomes”, which proposes that a unique ribosome composition determines the translational activity of this ribosome. The current review will present how technological advances have participated in the emergence of this concept, and to which extent the literature sustains this concept today. View Full-Text
Share & Cite This Article
Dalla Venezia, N.; Vincent, A.; Marcel, V.; Catez, F.; Diaz, J.-J. Emerging Role of Eukaryote Ribosomes in Translational Control. Int. J. Mol. Sci. 2019, 20, 1226.
Dalla Venezia N, Vincent A, Marcel V, Catez F, Diaz J-J. Emerging Role of Eukaryote Ribosomes in Translational Control. International Journal of Molecular Sciences. 2019; 20(5):1226.Chicago/Turabian Style
Dalla Venezia, Nicole; Vincent, Anne; Marcel, Virginie; Catez, Frédéric; Diaz, Jean-Jacques. 2019. "Emerging Role of Eukaryote Ribosomes in Translational Control." Int. J. Mol. Sci. 20, no. 5: 1226.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.