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Emerging Role of Eukaryote Ribosomes in Translational Control

Univ Lyon, Université Claude Bernard Lyon 1, Inserm U1052, CNRS UMR5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, 69008 Lyon, France
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Int. J. Mol. Sci. 2019, 20(5), 1226; https://doi.org/10.3390/ijms20051226
Received: 21 February 2019 / Revised: 6 March 2019 / Accepted: 8 March 2019 / Published: 11 March 2019
(This article belongs to the Special Issue Translational Control)
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Abstract

Translation is one of the final steps that regulate gene expression. The ribosome is the effector of translation through to its role in mRNA decoding and protein synthesis. Many mechanisms have been extensively described accounting for translational regulation. However it emerged only recently that ribosomes themselves could contribute to this regulation. Indeed, though it is well-known that the translational efficiency of the cell is linked to ribosome abundance, studies recently demonstrated that the composition of the ribosome could alter translation of specific mRNAs. Evidences suggest that according to the status, environment, development, or pathological conditions, cells produce different populations of ribosomes which differ in their ribosomal protein and/or RNA composition. Those observations gave rise to the concept of “specialized ribosomes”, which proposes that a unique ribosome composition determines the translational activity of this ribosome. The current review will present how technological advances have participated in the emergence of this concept, and to which extent the literature sustains this concept today. View Full-Text
Keywords: specialized ribosome; ribosome composition; rRNA modification; ribosomal protein; translational regulation specialized ribosome; ribosome composition; rRNA modification; ribosomal protein; translational regulation
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Dalla Venezia, N.; Vincent, A.; Marcel, V.; Catez, F.; Diaz, J.-J. Emerging Role of Eukaryote Ribosomes in Translational Control. Int. J. Mol. Sci. 2019, 20, 1226.

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