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Article

Epigenome-Wide Association Study (EWAS) of Blood Lipids in Healthy Population from STANISLAS Family Study (SFS)

1
Université de Lorraine, Inserm, IGE-PCV, 54000 Nancy, France
2
Queen Mary University of London, E1 4NS London, UK
3
Randox Laboratories Ltd, Crumlin, BT29 4XL County Antrim, UK
4
Department of Internal Medicine and Geriatrics, CHU Nancy-Brabois, 54000 Nancy, France
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(5), 1014; https://doi.org/10.3390/ijms20051014
Received: 9 January 2019 / Revised: 10 February 2019 / Accepted: 21 February 2019 / Published: 26 February 2019
(This article belongs to the Section Molecular Genetics and Genomics)
Epigenome-Wide Association Studies (EWAS) are furthering our knowledge of epigenetic modifications involved in the regulation of lipids’ metabolism. Furthermore, epigenetic patterns associated with lipid levels may play an important role in predicting the occurrence of cardiovascular events. To further investigate the relationship between methylation status and lipids, we performed an EWAS in 211 individuals from the STANISLAS Family study (SFS). Methylation at two CpG sites (PRKAG2; p = 1.39 × 10−8; KREMEN2; p = 5.75 × 10−9) were significantly associated with lipidomic profiles. Replication was sought in adipose tissue where one probe, cg08897188, was found to be nominally significant (KREMEN2; p = 0.0196). These results could provide new insight in the mechanisms underlying cardiovascular diseases and contribute to new therapeutic interventions. View Full-Text
Keywords: genetics; gene Expression/polymorphisms; lipids; adipose tissue; dyslipidemias; EWAS; DNA methylation; epigenetics genetics; gene Expression/polymorphisms; lipids; adipose tissue; dyslipidemias; EWAS; DNA methylation; epigenetics
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MDPI and ACS Style

Xie, T.; Gorenjak, V.; G. Stathopoulou, M.; Dadé, S.; Marouli, E.; Masson, C.; Murray, H.; Lamont, J.; Fitzgerald, P.; Deloukas, P.; Visvikis-Siest, S. Epigenome-Wide Association Study (EWAS) of Blood Lipids in Healthy Population from STANISLAS Family Study (SFS). Int. J. Mol. Sci. 2019, 20, 1014. https://doi.org/10.3390/ijms20051014

AMA Style

Xie T, Gorenjak V, G. Stathopoulou M, Dadé S, Marouli E, Masson C, Murray H, Lamont J, Fitzgerald P, Deloukas P, Visvikis-Siest S. Epigenome-Wide Association Study (EWAS) of Blood Lipids in Healthy Population from STANISLAS Family Study (SFS). International Journal of Molecular Sciences. 2019; 20(5):1014. https://doi.org/10.3390/ijms20051014

Chicago/Turabian Style

Xie, Ting, Vesna Gorenjak, Maria G. Stathopoulou, Sébastien Dadé, Eirini Marouli, Christine Masson, Helena Murray, John Lamont, Peter Fitzgerald, Panagiotis Deloukas, and Sophie Visvikis-Siest. 2019. "Epigenome-Wide Association Study (EWAS) of Blood Lipids in Healthy Population from STANISLAS Family Study (SFS)" International Journal of Molecular Sciences 20, no. 5: 1014. https://doi.org/10.3390/ijms20051014

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