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Erratum published on 9 April 2019, see Int. J. Mol. Sci. 2019, 20(7), 1756.
Open AccessArticle

Ginseng Berry Extract Rich in Phenolic Compounds Attenuates Oxidative Stress but not Cardiac Remodeling post Myocardial Infarction

1
Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, MB R2H2A6, Canada
2
Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R2H2A6, Canada
3
Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB R3E0J9, Canada
4
Agriculture and Agri-Food Canada,Winnipeg, MB R2H2A6, Canada
5
Asper Clinical Research Institute & Office of Clinical Research, St. Boniface Hospital, Winnipeg, MB R2H2A6, Canada
6
Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R3T2N2, Canada
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(4), 983; https://doi.org/10.3390/ijms20040983
Received: 22 December 2018 / Revised: 14 February 2019 / Accepted: 20 February 2019 / Published: 24 February 2019
(This article belongs to the Special Issue Nutrition and Cardiovascular Health)
The cardioprotective effects of ginseng root extracts have been reported. However, nothing is known about the myocardial actions of the phenolic compounds enriched in ginseng berry. Therefore, this study was undertaken to investigate the effects of American ginseng berry extract (GBE) in an experimental model of myocardial infarction (MI). Coronary artery ligation was performed on Sprague–Dawley male rats to induce MI after which animals were randomized into groups receiving either distilled water or GBE intragastrically for 8 weeks. Echocardiography and assays for malondialdehyde (MDA) and TNF-α were conducted. Flow cytometry was used to test the effects of GBE on T cell phenotypes and cytokine production. Although GBE did not improve the cardiac functional parameters, it significantly attenuated oxidative stress in post-MI rat hearts. GBE treatment also resulted in lower than control levels of TNF-α in post-MI rat hearts indicating a strong neutralizing effect of GBE on this cytokine. However, there was no effect of GBE on the proportion of different T cell subsets or ex-vivo cytokine production. Taken together, the present study demonstrates GBE reduces oxidative stress, however no effect on cardiac structure and function in post-MI rats. Moreover, reduction of TNF-α levels below baseline raises concern regarding its use as prophylactic or preventive adjunct therapy in cardiovascular disease. View Full-Text
Keywords: Panax quinquefolius; ginseng berry; myocardial infarction; phenolic compounds Panax quinquefolius; ginseng berry; myocardial infarction; phenolic compounds
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MDPI and ACS Style

Parikh, M.; Raj, P.; Yu, L.; Stebbing, J.-A.; Prashar, S.; Petkau, J.C.; Tappia, P.S.; Pierce, G.N.; Siow, Y.L.; Brown, D.; Blewett, H.; Netticadan, T. Ginseng Berry Extract Rich in Phenolic Compounds Attenuates Oxidative Stress but not Cardiac Remodeling post Myocardial Infarction. Int. J. Mol. Sci. 2019, 20, 983. https://doi.org/10.3390/ijms20040983

AMA Style

Parikh M, Raj P, Yu L, Stebbing J-A, Prashar S, Petkau JC, Tappia PS, Pierce GN, Siow YL, Brown D, Blewett H, Netticadan T. Ginseng Berry Extract Rich in Phenolic Compounds Attenuates Oxidative Stress but not Cardiac Remodeling post Myocardial Infarction. International Journal of Molecular Sciences. 2019; 20(4):983. https://doi.org/10.3390/ijms20040983

Chicago/Turabian Style

Parikh, Mihir; Raj, Pema; Yu, Liping; Stebbing, Jo-Ann; Prashar, Suvira; Petkau, Jay C.; Tappia, Paramjit S.; Pierce, Grant N.; Siow, Yaw L.; Brown, Dan; Blewett, Heather; Netticadan, Thomas. 2019. "Ginseng Berry Extract Rich in Phenolic Compounds Attenuates Oxidative Stress but not Cardiac Remodeling post Myocardial Infarction" Int. J. Mol. Sci. 20, no. 4: 983. https://doi.org/10.3390/ijms20040983

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