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Open AccessReview

Activated Protein C in Cutaneous Wound Healing: From Bench to Bedside

1
Sutton Arthritis Research Laboratory, Kolling Institute of Medical Research, Sydney Medical School, Northern Clinical School, University of Sydney, Sydney, NSW 2065, Australia
2
Murray Maxwell Biomechanics Laboratory, Kolling Institute of Medical Research, Sydney Medical School, Northern Clinical School, University of Sydney, Sydney, NSW 2065, Australia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(4), 903; https://doi.org/10.3390/ijms20040903
Received: 24 January 2019 / Revised: 14 February 2019 / Accepted: 16 February 2019 / Published: 19 February 2019
(This article belongs to the Special Issue Inflammatory Skin Conditions 2018)
Independent of its well-known anticoagulation effects, activated protein C (APC) exhibits pleiotropic cytoprotective properties. These include anti-inflammatory actions, anti-apoptosis, and endothelial and epithelial barrier stabilisation. Such beneficial effects have made APC an attractive target of research in a plethora of physiological and pathophysiological processes. Of note, the past decade or so has seen the emergence of its roles in cutaneous wound healing—a complex process involving inflammation, proliferation and remodelling. This review will highlight APC’s functions and mechanisms, and detail its pre-clinical and clinical studies on cutaneous wound healing. View Full-Text
Keywords: activated protein C; wound healing; cytoprotection; cell culture; animal models; clinical trials activated protein C; wound healing; cytoprotection; cell culture; animal models; clinical trials
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Zhao, R.; Lin, H.; Bereza-Malcolm, L.; Clarke, E.; Jackson, C.J.; Xue, M. Activated Protein C in Cutaneous Wound Healing: From Bench to Bedside. Int. J. Mol. Sci. 2019, 20, 903.

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