Next Article in Journal
GmZPR3d Interacts with GmHD-ZIP III Proteins and Regulates Soybean Root and Nodule Vascular Development
Next Article in Special Issue
Detection and Correlation of Single and Concomitant TP53, PTEN, and CDKN2A Alterations in Gliomas
Previous Article in Journal
Proteomic Analysis of the Effect of Inorganic and Organic Chemicals on Silver Nanoparticles in Wheat
Open AccessReview

From Human Cytogenetics to Human Chromosomics

Jena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Am Klinikum 1, D-07747 Jena, Germany
Int. J. Mol. Sci. 2019, 20(4), 826; https://doi.org/10.3390/ijms20040826
Received: 10 January 2019 / Revised: 30 January 2019 / Accepted: 12 February 2019 / Published: 14 February 2019
(This article belongs to the Special Issue Chromosome and Karyotype Variation)
Background: The concept of “chromosomics” was introduced by Prof. Uwe Claussen in 2005. Herein, the growing insights into human chromosome structure finally lead to a “chromosomic view” of the three-dimensional constitution and plasticity of genes in interphase nuclei are discussed. This review is dedicated to the memory of Prof. Uwe Claussen (30 April 1945–20 July 2008). Recent findings: Chromosomics is the study of chromosomes, their three-dimensional positioning in the interphase nucleus, the consequences from plasticity of chromosomal subregions and gene interactions, the influence of chromatin-modification-mediated events on cells, and even individuals, evolution, and disease. Progress achieved in recent years is summarized, including the detection of chromosome-chromosome-interactions which, if damaged, lead to malfunction and disease. However, chromosomics in the Human Genetics field is not progressing presently, as research interest has shifted from single cell to high throughput, genomic approaches. Conclusion: Chromosomics and its impact were predicted correctly in 2005 by Prof. Claussen. Although some progress was achieved, present reconsiderations of the role of the chromosome and the single cell in Human Genetic research are urgently necessary. View Full-Text
Keywords: chromosomes; cytogenetics; chromosomics; interphase-architecture; epigenetics chromosomes; cytogenetics; chromosomics; interphase-architecture; epigenetics
Show Figures

Figure 1

MDPI and ACS Style

Liehr, T. From Human Cytogenetics to Human Chromosomics. Int. J. Mol. Sci. 2019, 20, 826.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop