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Int. J. Mol. Sci. 2019, 20(4), 794;

Sleep, Autonomic Nervous Function and Atherosclerosis

Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan
Author to whom correspondence should be addressed.
Received: 8 January 2019 / Revised: 4 February 2019 / Accepted: 7 February 2019 / Published: 13 February 2019
(This article belongs to the Special Issue Pathomechanisms of Atherosclerosis. Part II)
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Behavioral and psychosocial factors related to development of cardiovascular disease have been gaining increased attention. Notably, sleep is considered to be one of the most important behavioral factors involved in progression of atherosclerosis and cardiovascular events, with autonomic nervous function a potential mechanism. Several studies have shown associations of sleep and autonomic dysfunction with major surrogate markers of atherosclerosis, such as carotid intima-media thickness and arterial stiffness. Endocrinological, immunological, oxidative, inflammatory, and metabolic responses, as well as endothelial dysfunction may mediate the effects of the autonomic nervous system. For this review, we examined recent findings related to sleep, autonomic nervous dysfunction, and atherosclerosis, with the aim of understanding the involved pathophysiological mechanisms. View Full-Text
Keywords: sleep; autonomic nervous dysfunction; atherosclerosis; obesity; fatigue; cardiovascular disease sleep; autonomic nervous dysfunction; atherosclerosis; obesity; fatigue; cardiovascular disease

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Kadoya, M.; Koyama, H. Sleep, Autonomic Nervous Function and Atherosclerosis. Int. J. Mol. Sci. 2019, 20, 794.

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