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Int. J. Mol. Sci. 2019, 20(3), 743; https://doi.org/10.3390/ijms20030743

Design of Novel Oligomeric Mixed Ligand Complexes: Preparation, Biological Applications and the First Example of Their Nanosized Scale

1
Department of Chemistry, Taibah University, Al-Madinah Al-Munawarah 30002, Saudi Arabia
2
Chemistry Department, Faculty of Science, Ain Shams University, Cairo 11566, Egypt
*
Author to whom correspondence should be addressed.
Received: 10 January 2019 / Revised: 30 January 2019 / Accepted: 3 February 2019 / Published: 10 February 2019
(This article belongs to the Section Materials Science)
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Abstract

A successful oligomerization of ternary metal complexes, cobalt (II), nickel (II), copper (II), zinc (II), chromium (III) and ferric sulfate (III) with nitrilotriacetic acid (NTA) as a primary ligand and glutamic acid as a secondary ligand, has been demonstrated. The formation of oligomers arose from the presence of the sulfate moiety, which operates as a bridged bidentate ligand that coordinates with other metal moieties. The novel oligomers exhibited octahedral structures, which bonded together through the sulfate moiety. In silico predictions were conducted to gauge the bioactivity, physico-chemical and pharmacokinetic properties. The biological activities of these oligomers as well as their tumor inhibitory behavior have been explored. This work also presents a facile and novel method of preparing these materials in nanosize, using Cetyltrimethylammonium bromide (CTAB) and polyvinyl alcohol (PVA) as capping ligands. The size and shape of the nanomaterials have been confirmed using the transmission electron microscope (TEM) and the scanning electron microscope (SEM). View Full-Text
Keywords: ternary complexes; oligomers; nanoparticles; in silico predictions; antimicrobial activity; antitumor behavior ternary complexes; oligomers; nanoparticles; in silico predictions; antimicrobial activity; antitumor behavior
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Okasha, R.M.; AL-Shaikh, N.E.; Aljohani, F.S.; Naqvi, A.; Ismail, E.H. Design of Novel Oligomeric Mixed Ligand Complexes: Preparation, Biological Applications and the First Example of Their Nanosized Scale. Int. J. Mol. Sci. 2019, 20, 743.

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