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Advanced Materials and Devices for the Regulation and Study of NK Cells

Department of Materials Engineering, Ilse Katz Institute for Nanoscale Science & Technology, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel
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Int. J. Mol. Sci. 2019, 20(3), 646; https://doi.org/10.3390/ijms20030646
Received: 18 December 2018 / Revised: 24 January 2019 / Accepted: 29 January 2019 / Published: 2 February 2019
(This article belongs to the Special Issue Advances in NK Cell Receptors and Their Ligands)
Natural Killer (NK) cells are innate lymphocytes that contribute to immune protection by cytosis, cytokine secretion, and regulation of adaptive responses of T cells. NK cells distinguish between healthy and ill cells, and generate a cytotoxic response, being cumulatively regulated by environmental signals delivered through their diverse receptors. Recent advances in biomaterials and device engineering paved the way to numerous artificial microenvironments for cells, which produce synthetic signals identical or similar to those provided by the physiological environment. In this paper, we review recent advances in materials and devices for artificial signaling, which have been applied to regulate NK cells, and systematically study the role of these signals in NK cell function. View Full-Text
Keywords: NK cells; immune signaling; biomaterials; nanodevices; artificial immune synapse NK cells; immune signaling; biomaterials; nanodevices; artificial immune synapse
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Le Saux, G.; Schvartzman, M. Advanced Materials and Devices for the Regulation and Study of NK Cells. Int. J. Mol. Sci. 2019, 20, 646.

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