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Review
Peer-Review Record

The Paroxysmal Depolarization Shift: Reconsidering Its Role in Epilepsy, Epileptogenesis and Beyond

Int. J. Mol. Sci. 2019, 20(3), 577; https://doi.org/10.3390/ijms20030577
by Helmut Kubista *, Stefan Boehm and Matej Hotka
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Reviewer 3: Anonymous
Int. J. Mol. Sci. 2019, 20(3), 577; https://doi.org/10.3390/ijms20030577
Submission received: 8 January 2019 / Accepted: 24 January 2019 / Published: 29 January 2019
(This article belongs to the Special Issue Epilepsy: From Molecular Mechanisms to Targeted Therapies)

Round 1

Reviewer 1 Report

This manuscript reviews the mechanism and role of paroxysmal depolarization shift (PDS) in epilepsy.  The authors describe the ionic basis of PDS and introduces two controversial hypotheses regarding its role in epilepsy.  This is a good introduction of this topic and the contents are well-organized.

Reviewer 2 Report

Excellent manuscript. An elegant and informative review of a complicated topic.

Reviewer 3 Report

In this article, the authors reviewed the mechanisms of PDS, the role of PDS in epilepsy and other neurological diseases, as well as future questions that need to be addressed. This article is very well written and informative. I highly recommend it for publication.

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