Next Article in Journal
Depletion of Akt1 and Akt2 Impairs the Repair of Radiation-Induced DNA Double Strand Breaks via Homologous Recombination
Next Article in Special Issue
Reduced Levels of Cerebrospinal Fluid/Plasma Aβ40 as an Early Biomarker for Cerebral Amyloid Angiopathy in RTg-DI Rats
Previous Article in Journal
Evaluation of Milk Colostrum Derived Lactoferrin of Sahiwal (Bos indicus) and Karan Fries (Cross-Bred) Cows for Its Anti-Cancerous Potential
Previous Article in Special Issue
Norvaline Restores the BBB Integrity in a Mouse Model of Alzheimer’s Disease
Open AccessReview
Peer-Review Record

The Amyloid-Tau-Neuroinflammation Axis in the Context of Cerebral Amyloid Angiopathy

Int. J. Mol. Sci. 2019, 20(24), 6319;
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2019, 20(24), 6319;
Received: 30 November 2019 / Revised: 10 December 2019 / Accepted: 12 December 2019 / Published: 14 December 2019
(This article belongs to the Special Issue Cerebral Amyloid Angiopathy: Causes, Diagnosis and Treatment)

Round 1

Reviewer 1 Report

The manuscript authored by Cisternas P. et al. is an interesting review about the Amyloid-Tau-Neuroinflammation axis in Cerebral Amyloid Angiopathy, in relation with beta-amyloid diversity. 

Despite the manuscript is well-written and balanced, here below my concerns and suggestions:

1) carefully revise the manuscript concearning English editing. In details, at lines 45-49 (rephrase 47-48). Sobstitute "leading to further increased amyloid accumulation" with "leading to a further increase in amyloid accumulation". Revise lines 266,287 and 320. 

2) The titles of the chapters are to a broader extent, thus in turn modify them being more specific.

3) When possible include subparagraph for each chapter, thus to be more reader friendly. 

4) Revise Fig.1 not using the same colour for Amyloif fibrils and microglia thus to be more evident and not to leave empty the inner of the vasculature not to mislead the reader. 


Author Response

Please see attachment

Author Response File: Author Response.pdf

Reviewer 2 Report

I did not find any issues in this paper; I can only send congratulations for the Authors and recommend this manuscript for publication in IJMS.

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Back to TopTop