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Metabolic Health—The Role of Adipo-Myokines

by 1,2,*,† and 2,†
Department for physical activity in public health, Institute of Movement and Neurosciences, Am Sportpark Müngersdorf 6, German Sport University Cologne, 50933 Cologne, Germany
Cologne Center for Prevention in Childhood and Youth/Heart Center Cologne, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany
Author to whom correspondence should be addressed.
Authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(24), 6159;
Received: 12 November 2019 / Revised: 2 December 2019 / Accepted: 4 December 2019 / Published: 6 December 2019
(This article belongs to the Special Issue Adipokines 2.0)
Obesity is now a worldwide epidemic. In recent years, different phenotypes of obesity, ranging from metabolically healthy normal weight to metabolically unhealthy obese, were described. Although there is no standardized definition for these phenotypes or for metabolic health, the influence of lifestyle and early-life factors is undisputed. In this context, the ratio of muscle-to-fat tissue seems to play a crucial role. Both adipose tissue and skeletal muscle are highly heterogeneous endocrine organs secreting several hormones, with myokines and adipokines being involved in local autocrine/paracrine interactions and crosstalk with other tissues. Some of these endocrine factors are secreted by both tissues and are, therefore, termed adipo-myokines. High (cardiorespiratory) fitness as a surrogate parameter for an active lifestyle is epidemiologically linked to “better” metabolic health, even in the obese; this may be partly due to the role of adipo-myokines and the crosstalk between adipose and muscle tissue. Therefore, it is essential to consider (cardiovascular) fitness in the definition of metabolically healthy obese/metabolic health and to perform longitudinal studies in this regard. A better understanding of both the (early-life) lifestyle factors and the underlying mechanisms that mediate different phenotypes is necessary for the tailored prevention and personalized treatment of obesity. View Full-Text
Keywords: adipokine; myokine; fitness; metabolically healthy obese; early-life programming adipokine; myokine; fitness; metabolically healthy obese; early-life programming
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MDPI and ACS Style

Graf, C.; Ferrari, N. Metabolic Health—The Role of Adipo-Myokines. Int. J. Mol. Sci. 2019, 20, 6159.

AMA Style

Graf C, Ferrari N. Metabolic Health—The Role of Adipo-Myokines. International Journal of Molecular Sciences. 2019; 20(24):6159.

Chicago/Turabian Style

Graf, Christine, and Nina Ferrari. 2019. "Metabolic Health—The Role of Adipo-Myokines" International Journal of Molecular Sciences 20, no. 24: 6159.

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