Next Article in Journal
Celiac Disease Monocytes Induce a Barrier Defect in Intestinal Epithelial Cells
Previous Article in Journal
MicroRNA-Based Therapeutic Perspectives in Myotonic Dystrophy
Previous Article in Special Issue
Role of Phytochemicals in Cancer Prevention
Open AccessReview

Cellular Stress-Modulating Drugs Can Potentially Be Identified by in Silico Screening with Connectivity Map (CMap)

by Yurong Gao 1,†, Sungwoo Kim 1,†, Yun-Il Lee 2,* and Jaemin Lee 1,*
1
Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Korea
2
Well Aging Research Center, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(22), 5601; https://doi.org/10.3390/ijms20225601 (registering DOI)
Received: 1 October 2019 / Revised: 5 November 2019 / Accepted: 6 November 2019 / Published: 9 November 2019
(This article belongs to the Special Issue Chemopreventive Activities of Phytochemicals)
Accompanied by increased life span, aging-associated diseases, such as metabolic diseases and cancers, have become serious health threats. Recent studies have documented that aging-associated diseases are caused by prolonged cellular stresses such as endoplasmic reticulum (ER) stress, mitochondrial stress, and oxidative stress. Thus, ameliorating cellular stresses could be an effective approach to treat aging-associated diseases and, more importantly, to prevent such diseases from happening. However, cellular stresses and their molecular responses within the cell are typically mediated by a variety of factors encompassing different signaling pathways. Therefore, a target-based drug discovery method currently being used widely (reverse pharmacology) may not be adequate to uncover novel drugs targeting cellular stresses and related diseases. The connectivity map (CMap) is an online pharmacogenomic database cataloging gene expression data from cultured cells treated individually with various chemicals, including a variety of phytochemicals. Moreover, by querying through CMap, researchers may screen registered chemicals in silico and obtain the likelihood of drugs showing a similar gene expression profile with desired and chemopreventive conditions. Thus, CMap is an effective genome-based tool to discover novel chemopreventive drugs. View Full-Text
Keywords: cellular stress; endoplasmic reticulum stress; ER stress; mitochondrial stress; oxidative stress; hypoxia; connectivity map; CMap; drug discovery cellular stress; endoplasmic reticulum stress; ER stress; mitochondrial stress; oxidative stress; hypoxia; connectivity map; CMap; drug discovery
Show Figures

Figure 1

MDPI and ACS Style

Gao, Y.; Kim, S.; Lee, Y.-I.; Lee, J. Cellular Stress-Modulating Drugs Can Potentially Be Identified by in Silico Screening with Connectivity Map (CMap). Int. J. Mol. Sci. 2019, 20, 5601.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop