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Open AccessArticle

Systematic Elucidation of the Mechanism of Genistein against Pulmonary Hypertension via Network Pharmacology Approach

by 1,†, 2,†, 1, 2, 1,*, 2,* and 2,*
1
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
2
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(22), 5569; https://doi.org/10.3390/ijms20225569
Received: 9 September 2019 / Revised: 5 November 2019 / Accepted: 5 November 2019 / Published: 7 November 2019
: Numerous studies have shown that genistein has a good therapeutic effect on pulmonary hypertension (PH). However, there has been no systematic research performed yet to elucidate its exact mechanism of action in relation to PH. In this study, a systemic pharmacology approach was employed to analyze the anti-PH effect of genistein. Firstly, the preliminary predicted targets of genistein against PH were obtained through database mining, and then the correlation of these targets with PH was analyzed. After that, the protein-protein interaction network was constructed, and the functional annotation and cluster analysis were performed to obtain the core targets and key pathways involved in exerting the anti-PH effect of genistein. Finally, the mechanism was further analyzed via molecular docking of genistein with peroxisome proliferator-activated receptor γ (PPARγ). The results showed that the anti-PH effect of genistein may be closely related to PPARγ, apoptotic signaling pathway, and the nitric oxide synthesis process. This study not only provides new insights into the mechanism of genistein against PH, but also provides novel ideas for network approaches for PH-related research. View Full-Text
Keywords: genistein; pulmonary hypertension; network pharmacology; peroxisome proliferator-activated receptor γ (PPARγ); molecular docking genistein; pulmonary hypertension; network pharmacology; peroxisome proliferator-activated receptor γ (PPARγ); molecular docking
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MDPI and ACS Style

Chen, Y.; Chen, D.; Liu, S.; Yuan, T.; Guo, J.; Fang, L.; Du, G. Systematic Elucidation of the Mechanism of Genistein against Pulmonary Hypertension via Network Pharmacology Approach. Int. J. Mol. Sci. 2019, 20, 5569.

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